Prototype Design and Phantom Evaluation of a Device for Co-registered MRI/TRUS Imaging of the Prostate.
Prototype Design and Phantom Evaluation of a Device for Co-registered MRI/TRUS Imaging of the Prostate.
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用于前列腺联合配准 MRI/TRUS 成像的设备的原型设计和体模评估。
DOI：
10.1007/978-3-319-05666-1_16
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Tempany,ClareM
中科院分区：
文献类型：
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作者：
Fedorov,Andriy;Song,Sang-Eun;Kapur,Tina;Owen,Robert;Sugar,EmilyNeubauer;Nguyen,Paul;Wells3rd,WilliamM;Tempany,ClareM
磁共振成像 (MRI) 和经直肠超声 (TRUS) 均用于对疑似患有前列腺癌的男性进行成像干预，以进行诊断和治疗。由于 TRUS 的广泛可用性和易用性，人们普遍认为空间配准 MRI/TRUS 数据的可用性可以为前列腺组织的表征和介入指导提供最佳组合。为了提供这种空间对齐的数据，我们提出了一种设备来支持 MRI 和 TRUS 数据的共同配准采集，同时保持前列腺的稳定配置（形状）。我们提出了一种定制套管的设计和评估，该套管可以经直肠引入，并且可以容纳 TRUS 和直肠内 MRI 探头。我们在体模上的实验表明，使用该套管进行成像不会影响内部结构的分化，也不会影响 MR 采集的质量。然而，在 TRUS 数据中观察到并量化了信号和对比度的降低。讨论了可能的患者研究所需的设备的进一步评估和修改。
Magnetic Resonance Imaging (MRI) and transrectal Ultrasound (TRUS) are both used in imaging interventions in men suspected of having and with prostate cancer for diagnosis as well as treatment. Due to the widespread availability and ease of use of TRUS, it is widely acknowledged that availability of spatially registered MRI/TRUS data could provide the optimal combination for characterization of prostate tissue and interventional guidance. To provide such spatially aligned data, we propose a device to support co-registered acquisition of MRI and TRUS data while maintaining a stable configuration (shape) of the prostate. We present the design and evaluation of a custom sleeve that can be introduced transrectally, and can accommodate both TRUS and endorectal MRI probes. Our experiments on a phantom have demonstrated that imaging with this sleeve did not compromise differentiation of internal structures and did not affect the quality of the MR acquisition. Reduction of the signal and contrast were however observed and quantified in the TRUS data. Further evaluation and modification of the device necessary for possible patient studies are discussed.