LIPOPROTEINS, CARDIOVASCULAR-DISEASE, AND DEATH - THE FRAMINGHAM-STUDY
LIPOPROTEINS, CARDIOVASCULAR-DISEASE, AND DEATH - THE FRAMINGHAM-STUDY
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DOI：
10.1001/archinte.141.9.1128
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发表时间：
1981-01-01
影响因子：
--
通讯作者：
DAWBER, TR
中科院分区：
文献类型：
--
作者：
GORDON, T;KANNEL, WB;DAWBER, TR
根据对49-82岁的Framingham男性和女性6年的随访评估，低密度脂蛋白（LDL）胆固醇浓度与冠心病（CHD）风险发生率低相关，但与女性卒中发生率和男女非冠心病原因死亡的统计学显著性增加相关。没有证据表明高密度脂蛋白胆固醇水平升高与任何心血管终点或死亡的发生率过高有关。高密度脂蛋白（HDL）胆固醇水平与冠心病及其主要后果冠心病死亡和充血性心力衰竭呈负相关。与高密度脂蛋白、低密度脂蛋白和其他已知的心血管危险因素相比，甘油三酯的测定似乎对心血管风险的影响不大。虽然HDL和LDL胆固醇与冠心病的关系与各种来源的发现是一致的，但LDL胆固醇与女性中风和非冠心病原因死亡的负相关关系需要进一步的证实和探索。
Based on 6 yr of follow-up evaluations of the Framingham men and women aged 49-82 yr, a low-density lipoprotein (LDL) cholesterol concentration was associated with a low incidence of coronary heart disease (CHD) risk but with a statistically significant excess of stroke incidence in women and of deaths from non-CHD causes in both sexes. There was no suggestion that an elevated HDL cholesterol level was associated with an excess incidence of any of the cardiovascular end points considered or of death. An inverse relation of high-density lipoprotein (HDL) cholesterol level with CHD and its major consequences, CHD death and congestive heart failure, was observed. Triglyceride determinations seem to add little information respecting cardiovascular risk to that elicited from HDL and LDL cholesterol and other known cardiovascular risk factors. While the relation of HDL and LDL cholesterol with CHD is paralleled by findings from a variety of sources, the inverse relation of LDL cholesterol with stroke in women and with death from non-CHD causes requires additional confirmation and exploration.