Cbl-b and itch: key regulators of peripheral T-cell tolerance.
Cbl-b and itch: key regulators of peripheral T-cell tolerance.
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DOI：
10.1158/0008-5472.can-09-4076
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发表时间：
2010-04-15
期刊：
影响因子：
11.2
通讯作者：
Venuprasad K
中科院分区：
文献类型：
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作者：
Venuprasad K
E3连接酶Cbl-b和Itch已经成为T细胞的主要“致耐受性”调节剂，因为它们的缺乏导致严重的自身免疫性疾病。Cbl-b和Itch连接酶活性通过调节TCR和TGF-β信号传导的关键组分来调节外周中的T细胞无反应性和Foxp 3 + T细胞的发育。Cbl-b和Itch活性的操纵可能为开发免疫疾病（如自身免疫和癌症）的未来疗法提供独特的机会
E3 ligases Cbl-b and Itch have emerged as dominant “tolerogenic” regulators of T cells because their deficiency results in severe autoimmune diseases. Cbl-b and Itch ligase activity regulate T cell anergy and development of Foxp3+ Tregs in the periphery by modulating key components of TCR and TGF-β signaling. Manipulation of Cbl-b and Itch activities may provide unique opportunities to develop future therapies for immune disorders such as autoimmunity and cancer