Increased production of autoantibodies and specific antibodies in response to influenza virus vaccination in physically active older individuals.
Increased production of autoantibodies and specific antibodies in response to influenza virus vaccination in physically active older individuals.
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DOI：
10.1016/j.rinim.2013.01.001
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发表时间：
2013-01-01
期刊：
影响因子：
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通讯作者：
Lopes, Jose D
中科院分区：
文献类型：
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作者：
Bachi, Andre L L;Suguri, Vinicius M;Lopes, Jose D
免疫衰老与衰老有关，据报道，在免疫反应的许多变化中，接种疫苗的反应减弱，自身免疫病例数量增加，这是由被称为天然抗体的自身抗体引起的，据报道，这种抗体的功能是防止感染和炎症。虽然免疫衰老是一个不可逆转的过程，但定期的适度运动可以缓解免疫系统的某些方面的下降。因此，本研究的目的是调查体力活动的老年人在接种流感病毒疫苗前和接种后30天的体液免疫反应。结果表明，经常运动组免疫后抗核抗体阳性百分率和血清免疫球蛋白M、G水平均高于久坐组。我们还能够证明天然自身抗体水平与接种疫苗的反应之间存在显著的相关性。
Immunosenescence is associated to aging and among many changes in immune response is reported a reduced response to vaccination and an increase in the number of cases of autoimmunity, caused by autoantibodies known as natural antibodies whose function, according to reports, would be protection against infection and inflammation. Although immunosenescence is an irreversible process, regular moderate exercise can attenuate some aspects of the decline in the immune system. So, the aim of this study was to investigate the humoral immune response in physically active elderly individuals before and 30 days after vaccination against influenza virus. The results showed that the percentage of individuals positive for antinuclear antibodies and serum immunoglobulin M and G levels after vaccination were higher in the group that exercised regularly than in the sedentary group. We were also able to demonstrate a significant correlation between levels of natural autoantibodies and response to vaccination.