Differential distribution of Y-box-binding protein 1 and cold shock domain protein A in developing and adult human brain
Differential distribution of Y-box-binding protein 1 and cold shock domain protein A in developing and adult human brain
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DOI：
10.1007/s00429-014-0786-9
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发表时间：
2015-07-01
影响因子：
3.1
通讯作者：
Mertens, Peter R.
中科院分区：
文献类型：
--
作者：
Bernstein, Hans-Gert;Lindquist, Jonathan A.;Mertens, Peter R.
两个冷休克结构域包含蛋白，Y-盒结合蛋白-1和冷休克结构域蛋白A的免疫定位在发育和成年人脑。除少数下丘脑星形胶质细胞外，脑Y-盒结合蛋白-1主要存在于成熟的人CNS的多个神经元中，这可能与其参与神经传递和其他神经元相关功能有关。冷休克结构域蛋白A主要见于星形胶质细胞、少突胶质细胞、脉络丛上皮细胞和神经纤维。然而，在下丘脑、缰核和小脑等特定脑区，这种蛋白质也在神经元中表达。在出生前的大脑中，这两种蛋白质被发现大量表达在放射状胶质细胞，神经母细胞和神经元，这可能是一个解剖学相关的两种蛋白质在细胞增殖和分化中的作用。此外，在培养的脂多糖刺激的小胶质细胞中鉴定了Y-盒结合蛋白-1，这强调了其作为免疫和炎症过程中的介质的假定作用。
The two cold shock domain containing proteins, Y-box-binding protein-1 and cold shock domain protein A were immunolocalized in developing and adult human brain. With the exception of a small population of hypothalamic astrocytes, brain Y-box-binding protein-1 was predominantly found in multiple neurons in the mature human CNS, which might be related to its involvement in neurotransmission and other neuron-associated functions. Cold shock domain protein A was typically observed in astrocytes, oligodendrocytes, choroid plexus epithelia and nerve fibers. However, in circumscribed brain regions as hypothalamus, habenula, and cerebellum, this protein was also expressed in neurons. In the prenatal brain, both proteins were found to be abundantly expressed in radial glial cells, neuroblasts and neurons, which might be an anatomical correlate of the proposed roles of both proteins in cell proliferation and differentiation. In addition, Y-box-binding protein-1 was identified in cultured, lipopolysaccharide-stimulated microglial cells, which underscores its putative role as a mediator in immune and inflammatory processes.