Effect of subchronic dieldrin treatment on calmodulin-regulated Ca2+ pump activity in rat brain.
Effect of subchronic dieldrin treatment on calmodulin-regulated Ca2+ pump activity in rat brain.
复制标题
亚慢性狄氏剂治疗对大鼠脑内钙调素调节的 Ca2 泵活性的影响。
DOI：
10.1080/15287398809531224
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Desaiah,D
中科院分区：
文献类型：
--
作者：
Mehrotra,BD;RavichandraReddy,S;Desaiah,D
在体内用10 ppm狄氏剂处理60天的Sprague-道利大鼠的脑P2部分中测定钙调素依赖性（CaM依赖性）和非依赖性Ca 2+泵活性。在狄氏剂中毒40天后，发现每日摄食量和体重增加受到影响。狄氏剂抑制CaM依赖性和非依赖性Ca 2 +-ATP酶活性，中毒60 d后酶活性分别降至36%（CaM依赖性）和18%（基础）。脑钙调素水平的降低和随后对Ca 2 +-ATP酶活性的抑制表明，极低剂量的狄氏剂慢性中毒改变了钙调素及其对Ca 2 +-ATP酶活性的调节。
Calmodulin‐dependent (CaM‐dependent) and nondependent Ca2+pump activity was determined in the brain P2fraction of Sprague‐Dawley rats treated in vivo with 10 ppm dieldrin for 60 d. After 40 d of dieldrin intoxication, daily food consumption and body weight gain were found to be affected. Dieldrin inhibited both CaM‐dependent and ‐independent Ca2+‐ATPase activity and the enzyme activity decreased to 36% (CaM‐dependent)—and 18% (basal) respectively after 60 d of intoxication. Reduction in brain CaM levels and a subsequent inhibition of Ca2+‐ATPase activity suggests that chronic intoxication of dieldrin at very low doses alters calmodulin and its regulation of Ca2+‐ATPase activity.