Odor-guided behavior in Drosophila requires calreticulin.
Odor-guided behavior in Drosophila requires calreticulin.
复制标题
果蝇的气味引导行为需要钙网蛋白。
DOI：
10.1007/s00359-003-0425-z
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Grotewiel,MS
中科院分区：
文献类型：
--
作者：
Stoltzfus,JR;Horton,WJ;Grotewiel,MS
The efficient processing of olfactory information is crucial for many aspects of life in animals, including behavior in insects. While much is known about the organization of the insect olfactory system, comparatively little is understood about the molecules that support its function. To further elucidate the molecular basis of olfaction, we explored the role of the calcium-binding chaperone calreticulin in the behavioral response ofDrosophilato aversive odorants. We show that avoidance of naturally aversive odorants is impaired in flies harboring mutations inCalreticulin.Calreticulinmutants have broad defects in odor avoidance without abnormalities in antennal responses to odorants, alterations in central nervous system structure, or deficits in overall locomotor abilities. Interestingly,Calreticulinmutants exhibit defects in behavioral responses to odorants at low strength, whereas responses to higher odorant concentrations are preserved in these animals. Our studies indicate that calreticulin plays a key role in olfactory system function, possibly by establishing its overall sensitivity to odorants.
