FUNCTIONAL ORGANIZATION OF A CORTICAL EFFERENT SYSTEM EXAMINED WITH FOCAL DEPTH STIMULATION IN CATS
FUNCTIONAL ORGANIZATION OF A CORTICAL EFFERENT SYSTEM EXAMINED WITH FOCAL DEPTH STIMULATION IN CATS
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DOI：
10.1152/jn.1967.30.1.35
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发表时间：
1967-01-01
影响因子：
2.5
通讯作者：
SAKATA, H
中科院分区：
文献类型：
--
作者：
ASANUMA, H;SAKATA, H
应用于运动皮层深度的重复局灶性阴极刺激导致前臂肌肉神经的单突触反射的促进和抑制，其电流比麻醉猫的表面阳极刺激小得多。给定肌肉神经的低阈值点被限制在灰质内的受限区域内，而阈值在白色物质中增加。在有效区的边界，阈值通常突然升高。有效区的截面呈不规则形，直径从几百μ到几mm不等，平均为1 mm，最低阈值电流为2.0 μ A（易化）和4.0 μ A（抑制）。锥体横断取消了这些低阈值皮层效应。在焦点处的一些锥体神经元的激活可能导致给定运动神经元池的兴奋性改变。
Repetitive focal cathodal stimulation applied to the depth of the motor cortex causes facilitation and inhibition of monosynaptic reflexes of forearm muscle nerves with much smaller currents than surface anodal stimulation of anesthetized cats. Low threshold points for a given muscle nerve are confined within a restricted zone within the gray matter whereas the threshold increases in the white substance. At the limits of effective zones, threshold usually elevates suddenly. Shapes of the effective zones in cross section are irregular and the diameters range from a few hundred [mu]to a few mm, the average being one mm. The lowest threshold currents found were 2.0 [mu]A for facilitation and 4.0 [mu]A for inhibition. Pyramidal transection abolished these low threshold cortical effects. Activation of a few pyramidal neurons at the focal point may result in altered excitability of a given motoneuron pool.