Current Advances of Innate and Adaptive Immunity in Acute-on-Chronic Hepatitis B Liver Failure
Current Advances of Innate and Adaptive Immunity in Acute-on-Chronic Hepatitis B Liver Failure
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DOI：
10.1097/id9.0000000000000051
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发表时间：
2022-03
期刊：
影响因子：
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通讯作者：
Liyuan Wang;Yuchen Fan
中科院分区：
文献类型：
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作者：
Liyuan Wang;Yuchen Fan
慢性加急性B型肝炎肝衰竭（ACHBLF）是指慢性B型肝炎病毒感染或B型肝炎病毒相关肝硬化患者肝功能急性恶化的一种疾病。ACHBLF的具体发病机制仍不完全清楚。目前的研究表明，强烈的全身炎症参与了慢加急性肝功能衰竭（ACLF）的发展。同时，在ACLF过程中随后的免疫轻瘫有利于感染和脓毒症的发展。先天免疫和获得性免疫的失调是ACLF的显著特征。免疫反应失调在疾病进展中起着至关重要的作用，并可能导致ACHBLF的器官衰竭和死亡率。在这篇综述中，我们强调了ACHBLF的先天性和适应性免疫细胞的现有知识。
Abstract Acute-on-chronic hepatitis B liver failure (ACHBLF) is a term used to define the acute deterioration of liver function that occurs in patients with chronic hepatitis B virus infection or hepatitis B virus-related liver cirrhosis. The specific pathogenesis of ACHBLF is still not completely understood. Current research has shown that an intense systemic inflammation is involved in the development of acute-on-chronic liver failure (ACLF). Meanwhile, a subsequent immune paresis over the course of ACLF favors the development of infection and sepsis. Deregulation in both the innate and adaptive immunity is the notable feature of ACLF. The dysregulated immune responses play a crucial role in disease progression and potentially drive organ failure and mortality in ACHBLF. In this review, we highlight the current knowledge of innate and adaptive immune cells in ACHBLF.