Dietary flavonoid fisetin for cancer prevention and treatment.
Dietary flavonoid fisetin for cancer prevention and treatment.
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DOI：
10.1002/mnfr.201600025
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发表时间：
2016-06
影响因子：
5.2
通讯作者：
Mukhtar H
中科院分区：
文献类型：
--
作者：
Lall RK;Adhami VM;Mukhtar H
癌症仍然是一个主要的公共卫生问题，也是世界范围内的一个重要死因。鉴定具有抑制致癌潜力的生物活性分子继续引起科学界的兴趣。特别是，来自膳食来源的类黄酮是最受欢迎的，因为它们的安全性，成本效益和口服给药的可行性。新出现的数据为理解分子机制提供了新的见解，这些分子机制对于确定癌症预防和治疗的新机制策略至关重要。在许多水果和蔬菜中发现的膳食类黄酮非瑟酮（3，3 ′，4 ′，7-四羟基黄酮）已在临床前研究中显示通过改变细胞周期、诱导凋亡、血管生成、侵袭和转移来抑制癌症生长，而不对正常细胞造成任何毒性。尽管来自体外和体内研究的数据看起来令人信服，但需要精心设计的人体临床试验来最终确定对各种癌症的疗效。本文综述了非瑟酮对各种癌症的化学预防和治疗作用、分子靶点和机制。
Cancer remains a major public health concern and a significant cause of death worldwide. Identification of bioactive molecules that have the potential to inhibit carcinogenesis continues to garner interest among the scientific community. In particular, flavonoids from dietary sources are the most sought after because of their safety, cost-effectiveness, and feasibility of oral administration. Emerging data have provided newer insights into understanding the molecular mechanisms that are essential to identify novel mechanism-based strategies for cancer prevention and treatment. Dietary flavonoid fisetin (3,3′,4′,7-tetrahydroxyflavone) found in many fruits and vegetables has been shown in preclinical studies to inhibit cancer growth through alteration of cell cycle, inducing apoptosis, angiogenesis, invasion, and metastasis without causing any toxicity to normal cells. Although data from in-vitro and in-vivo studies look convincing, well-designed clinical trials in humans are needed to conclusively determine the efficacy across various cancers. This review highlights the chemopreventive and therapeutic effects, molecular targets, and mechanisms that contribute to the observed anticancer activity of fisetin against various cancers.
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影响因子：
--
作者：
Lin, Ming-Te;Lin, Chia-Liang;Tsai, Jen-Pi
通讯作者：
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封装非瑟酮的聚合物胶束提高结肠癌的治疗效果
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
Mukhtar, Hasan
影响因子：
5
作者：
Kuntz, S;Wenzel, U;Daniel, H
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影响因子：
3.7
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通讯作者：
Nagaoka Y