CHROMOSOME ANALYSIS OF 97 PRIMARY BREAST-CARCINOMAS - IDENTIFICATION OF 8 KARYOTYPIC SUBGROUPS
CHROMOSOME ANALYSIS OF 97 PRIMARY BREAST-CARCINOMAS - IDENTIFICATION OF 8 KARYOTYPIC SUBGROUPS
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DOI：
10.1002/gcc.2870120304
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发表时间：
1995-03-01
影响因子：
3.7
通讯作者：
HEIM, S
中科院分区：
文献类型：
--
作者：
PANDIS, N;JIN, YS;HEIM, S
对 97 个短期培养的原发性乳腺癌的染色体显带分析显示，79 个肿瘤存在克隆畸变，而 18 个肿瘤核型正常。在 79 个异常肿瘤中的 34 个中，每个病例检测到 2 至 8 个克隆； unrelated clones were present in 27 (34%) cases, whereas only related clones were found in seven.这些发现表明很大一部分乳腺癌是多克隆起源的。总共八种异常被反复鉴定为严重的染色体异常和更复杂核型的一部分：结构重排 i(1)(q10)、der(1;16)(q10;p10)、del(1)(q11-12)、del(3)(p12-13p14-21) 和 del(6)(q21-22) 以及数值畸变 +7、+18 和 +20。在 41 个（52%）核型异常肿瘤中至少发现了其中一种变化。他们确定了乳腺癌中最少数量的细胞遗传学亚组，并且可能代表此类肿瘤中的原发性染色体异常。这种作用的其他候选者包括 3p12-13 和 4q21 与各种伴侣染色体的易位以及 7 号染色体的倒位，这些也反复出现。其他染色体畸变给人以非随机发生的印象，包括导致 1p、8p、11p、11q、15p、17p、19p 和 19q 部分单体的结构重排，以及 X、8、9、13、14、17 和 22 染色体一份拷贝的丢失。后者的变化仅在复杂的染色体中一致可见。然而，核型，因此我们 将它们解释为克隆进化过程中获得的次生异常。 (C) 1995 Wiley-Liss, Inc.
Chromosome banding analysis of 97 short-term cultured primary breast carcinomas revealed clonal aberrations in 79 tumors, whereas 18 were karyotypically normal. In 34 of the 79 tumors with abnormalities, two to eight clones per case were detected; unrelated clones were present in 27 (34%) cases, whereas only related clones were found in seven. These findings indicate that a substantial proportion of breast carcinomas are of polyclonal origin. Altogether eight abnormalities were repeatedly identified both as sore chromosomal anomalies and as part of more complex karyotypes: the structural rearrangements i(1)(q10), der(1;16)(q10;p10), del(1)(q11-12), del(3)(p12-13p14-21), and del(6)(q21-22) and the numerical aberrations +7, +18, and +20. At least one of these changes was found in 41 (52%) of the karyotypically abnormal tumors. They identify a minimum number of cytogenetic subgroups in breast cancer and are likely to represent primary chromosome anomalies in this type of neoplasia. Other candidates for such a role are translocations of 3p12-13 and 4q21 with various partner chromosomes and inversions of chromosome 7, which also were seen repeatedly. Additional chromosomal aberrations that give the impression of occurring nonrandomly in breast carcinomas include structural rearrangements leading to partial monosomies for 1p, 8p, 11p, 11q, 15p, 17p, 19p, and 19q and losses of one copy of chromosomes X, 8, 9, 13, 14, 17, and 22. The latter changes were seen consistently only in complex karyotypes, however, and we therefore interpret them as being secondary anomalies acquired during clonal evolution. (C) 1995 Wiley-Liss, Inc.