Fortifying the link between SIRT1, resveratrol, and mitochondrial function.

Fortifying the link between SIRT1, resveratrol, and mitochondrial function.
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DOI:
10.1016/j.cmet.2012.04.016
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发表时间:
2012-05-02
期刊:
影响因子:
29
通讯作者:
Denu JM
Denu JM
中科院分区:
生物学1区
文献类型:
--
作者:
Denu JM

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The molecular mechanisms behind the health benefits of resveratrol remain enigmatic and controversial. Here, Price et al. establish a clear chemical-genetic connection between SIRT1 and resveratrol, providing strong evidence that SIRT1 is critical for resveratrol to stimulate mitochondrial biogenesis and a switch toward oxidative muscle fibers.
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