Skeletal muscle perfusion during exercise using Gd-DTPA bolus detection
Skeletal muscle perfusion during exercise using Gd-DTPA bolus detection
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DOI：
10.3109/10976640009148690
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发表时间：
2000-01-01
影响因子：
6.4
通讯作者：
Kaijser, L
中科院分区：
文献类型：
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作者：
Nygren, AT;Greitz, D;Kaijser, L
该研究旨在评估是否可以使用静脉推注 Gd-DTPA 来确定运动时的骨骼肌灌注。快速破坏梯度回波序列（T1 加权）与不同工作负载下的单腿跖屈期间的间歇成像一起使用。在重复屈曲之间，休息 2 秒，以便对小腿进行磁共振成像 (MRI)，并通过超声检查测量腘动脉的血流量，以便随后计算肌肉灌注。在双边感兴趣区域内测量最大信号强度、推注的上坡和下坡、平均通过时间和积分曲线面积。通过超声检查估计的运动腿骨骼肌灌注从休息时的 4 ml (.) 100 g(-1) (.) min(-1) 增加到低负荷时的 38 ml、中负荷时的 86 ml 和高负荷时的 110 ml (.) 100 g(-1) (.) min(-1)。 SImax 从 1.38 +/- 0.12 增加到 1.58 +/- 0.15，峰值的负斜率从 - 2.38 +/- 1.75 不显着地增加到 - 12.05 +/- 9.71。所有获得的 MRI 参数都可以在视觉上将肌肉分为运动肌肉、非运动肌肉和可能低活跃的肌肉。结论是，使用快速破坏梯度回波序列的信号强度曲线并不能全面定量地反映灌注，评估为超声检查测量的血流量。然而，信号强度似乎遵循血流速度，限制范围为 15-60 cm (.) sec(-1)，对应于 35-90 ml (.) 100 g(-1) (.) min(-1)。尽管如此，在研究运动过程中骨骼肌的缺血或内皮功能障碍时，它可能很有用。
The study was performed to evaluate if skeletal muscle perfusion can be determined exercise using an IV bolus injection of Gd-DTPA. A fast spoiled gradient echo sequence (T1 weighted) was used with intermittent imaging during one-legged plantar flexion at different workloads. Between repetitive flexions, a 2-sec rest allowed magnetic resonance imaging (MRI) of the lower legs and measurements of the blood flow in the popliteal artery by ultrasonography for subsequent calculation of muscle perfusion. Maximal signal intensity, upslope and downslope of the bolus, mean transit time, and integrated curve area were measured within regions of interest bilaterally. The skeletal muscle perfusion estimated by ultrasonography increased in the exercising leg from 4 ml (.) 100 g(-1) (.) min(-1) at rest to 38 ml at low, 86 ml at medium, and 110 ml (.) 100 g(-1) (.) min(-1) at high workload. The SImax increased from 1.38 +/- 0.12 to 1.58 +/- 0.15 and the negative slope of the peak nonsignificantly from - 2.38 +/- 1.75 to - 12.05 +/- 9.71. All obtained MRI parameters could visually separate the muscles into exercising, nonexercising, and presumably low active muscles. It is concluded that the signal intensity curve using a fast spoiled gradient echo sequence did not overall quantitatively mirror the perfusion, evaluated as the blood flow measured by ultrasonography. However, the signal intensity seemed to follow the blood flow velocity with a limited range of 15-60 cm (.) sec(-1), corresponding to 35-90 ml (.) 100 g(-1) (.) min(-1). Nonetheless, it might be useful when studying ischemia or endothelial dysfunction in skeletal muscles during exercise.