Dynamic mechanical and swelling properties of maleated hyaluronic acid hydrogels
Dynamic mechanical and swelling properties of maleated hyaluronic acid hydrogels
复制标题
马来化透明质酸水凝胶的动态机械和溶胀性能
DOI：
10.1016/j.carbpol.2015.01.047
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发表时间：
2015-06-05
影响因子：
11.2
通讯作者：
Zhang, Xingdong
中科院分区：
文献类型：
--
作者：
Lin, Hai;Liu, Jun;Zhang, Xingdong
A series of maleated hyaluronan (MaHA) are developed by modification with maleic anhydride. The degrees of substitution (DS) of MaHA vary between 7% and 75%. The DS of MaHA is both higher and wider than methacrylated HA derivatives (MeHA) reported in the literature. MaHA hydrogels are then prepared by photopolymerization and their dynamic mechanical and swelling properties of the hydrogels are investigated. The results showed that MaHA hydrogels with moderate DS (25%, 50% and 65%) have higher storage modulus and lower equilibrium swelling ratios than those with either low or high DS (7%, 15% and 75%). Theoretical analyses also suggest a similar pattern among hydrogels with different DS. The results confirm that the increased cross-linking density enhances the strength of hydrogels. Meanwhile, the hydrophilicity of introduced groups during modification and the degree of incomplete crosslinking reaction might have negative impact on the mechanical and swelling properties of MaHA hydrogels. (C) 2015 Elsevier Ltd. All rights reserved.
