Investigation of association between LINC00673 rs11655237 C > T and Wilms tumor susceptibility
Investigation of association between LINC00673 rs11655237 C > T and Wilms tumor susceptibility
复制标题
LINC00673 rs11655237 C > T 与肾母细胞瘤易感性之间的关联研究
DOI：
10.1002/jcla.22930
复制
发表时间：
2019
影响因子：
2.7
通讯作者：
Liu Guochang
中科院分区：
文献类型：
--
作者：
Gao Xiaofeng;Jia Wei;Zhu Jinhong;Fu Wen;Zhu Shibo;Xia Huimin;He Jing;Liu Guochang
肾母细胞瘤（wilms tumor， WT）是儿童最常见的肾脏恶性肿瘤。先前的全基因组关联研究已经发现，inc00673rs11655237 C>T多态性与几种癌症的风险相关。然而，很少有研究调查linc00673rs11655237 C>T与WT易感性之间的关系。方法对145例WT患者和531例无癌对照进行linc00673rs11655237 C>T基因分型。关联强度通过比值比（ORs）和95%置信区间（ci）估计。结果我们的研究表明，在所有测试的遗传模型中，linc00673rs11655237 C>T多态性与WT风险之间没有显著相关性（CT vs CC：校正OR = 0.94, 95% CI = 0.63‐1.40；TT vs CC：校正OR = 0.60, 95% CI = 0.22‐1.59；TT/CT vs CC：校正OR = 0.89, 95% CI = 0.61‐1.31；TT vs CC/CT：校正OR = 0.61, 95% CI = 0.23‐1.61）。进一步的分层分析也没有发现显著的关联。总之，我们没有发现inc00673rs11655237 C>T多态性与WT风险之间的关联。这一发现需要在更大规模的研究和其他人群中得到证实。
BackgroundWilms tumor (WT) is the most common pediatric renal malignancy. Previous genome‐wide association studies have identified that theLINC00673rs11655237 C>T polymorphism is associated with the risk of several types of cancer. However, few studies have investigated the association betweenLINC00673rs11655237 C>T and WT susceptibility.MethodWe genotypedLINC00673rs11655237 C>T in 145 patients with WT and 531 cancer‐free controls recruited from southern Chinese children. The strength of association was estimated by odds ratios (ORs) and 95% confidence intervals (CIs).ResultsOur study indicated that there was no significant association betweenLINC00673rs11655237 C>T polymorphism and WT risk under all the tested genetic models (CT vs CC: adjusted OR = 0.94, 95% CI = 0.63‐1.40; TT vs CC: adjusted OR = 0.60, 95% CI = 0.22‐1.59; TT/CT vs CC: adjusted OR = 0.89, 95% CI = 0.61‐1.31; and TT vs CC/CT: adjusted OR = 0.61, 95% CI = 0.23‐1.61). Further stratified analysis detected no significant association, either.ConclusionIn conclusion, we failed to find any association between theLINC00673rs11655237 C>T polymorphism and WT risk. This finding needs to be verified in larger studies and other populations.