Sympathetic nerve activity in conscious renal hypertensive rats treated with an angiotensin converting enzyme inhibitor or an angiotensin II antagonist
Sympathetic nerve activity in conscious renal hypertensive rats treated with an angiotensin converting enzyme inhibitor or an angiotensin II antagonist
复制标题
用血管紧张素转换酶抑制剂或血管紧张素 II 拮抗剂治疗的清醒肾高血压大鼠的交感神经活动
DOI：
10.1097/00004872-199504000-00010
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发表时间：
1995
影响因子：
4.9
通讯作者：
B. Waeber
中科院分区：
文献类型：
--
作者：
M. Niederberger;J. Aubert;Jiirg Nussberger;H. Brunner;B. Waeber
目的观察清醒双肾一夹型高血压大鼠血管紧张素转换酶（ACE）抑制、血管紧张素II受体阻断和硝普钠血管舒张对动脉内平均血压、心率和脏器神经活性的影响。结果赖诺普利或氯沙坦（均为10mg/kg，静脉滴注）在2 h内均可引起平均血压的降低，而同期输注硝普钠（10μg/min）降低平均血压的作用较弱。心率在硝普钠输注期间比赖诺普利或氯沙坦治疗期间明显加快。只有给予硝普钠的大鼠内脏神经活动显著增加。在给药的大鼠中，所研究的参数没有变化。赖诺普利和氯沙坦分别在12 h和24 h后重复给药。最后一次给药前，患者平均血压仍较低。初始剂量24小时后再次给予赖诺普利或氯沙坦对平均血压、心率或内脏神经活动没有进一步的影响。结论：肾素依赖性高血压大鼠的实验结果表明，无论是由于ACE抑制还是血管紧张素II拮抗剂，阻断肾素-血管紧张素系统24小时都能产生相当程度的血压降低。结果还表明，当使用肾素-血管紧张素系统阻滞剂而不是直接使用硝普钠等血管扩张剂降低血压时，交感神经活动的反射激活较少。
Objective To assess in conscious two-kidney, one clip renal hypertensive rats whether angiotensin converting enzyme (ACE) inhibition with lisinopril, angiotensin II receptor blockade with losartan or vasodilation with sodium nitroprusside have similar effects on intra-arterial mean blood pressure, heart rate and splanchnic nerve activity. Results A bolus dose of lisinopril or losartan (both 10mg/kg, intravenously) induced within 2 h an equal reduction in mean blood pressure, whereas sodium nitroprusside infused during the same period (at 10μg/min) lowered mean blood pressure, but less strongly. The heart rate was accelerated significantly more during sodium nitroprusside infusion than during lisinopril or losartan treatment. Splanchnic nerve activity increased significantly only in those rats given sodium nitroprusside. No change in the parameters studied was observed in vehicle-treated rats. The doses of lisinopril and losartan were repeated after 12 and 24 h. Before administration of the last dose, the mean blood pressure was still low. Administration of lisinopril or losartan again 24 h after the initial dose had no further effect on the mean blood pressure, heart rate or splanchnic nerve activity. Conclusion These results obtained in rats with a renin-dependent form of hypertension show that blockade of the renin-angiotensin system for 24 h produces an equivalent blood pressure reduction irrespective of whether it is due to ACE inhibition or angiotensin II antagonism. The results also indicate that there is less reflex activation of sympathetic nerve activity when blood pressure is lowered with a blocker of the renin-angiotensin system rather than with a direct vasodilator such as sodium nitroprusside.