Clinical and metabolic characteristics of polycystic ovary syndrome without polycystic ovary: a pilot study on Chinese women
Clinical and metabolic characteristics of polycystic ovary syndrome without polycystic ovary: a pilot study on Chinese women
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无多囊卵巢的多囊卵巢综合征的临床和代谢特征：针对中国女性的初步研究
DOI：
10.1016/j.fertnstert.2007.07.1375
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发表时间：
2008-10-01
影响因子：
6.7
通讯作者：
Chen, Zijiang
中科院分区：
文献类型：
--
作者：
Shi, Yuhua;Gao, Xuan;Chen, Zijiang
目的：目的：探讨无多囊卵巢形态的多囊卵巢综合征（PCOS）患者亚组的临床特征。设计：回顾性研究。地点：医院IVF中心。患者：本研究中，876例PCOS患者选自2004年9月至2006年10月在山东大学附属山东省立医院生殖医学中心就诊的妇女。根据超声图像将PCOS患者分为两组：A组为典型多囊卵巢PCOS患者（n = 800）; B组为无多囊卵巢形态的PCOS患者（n = 76）。以下可用的数据进行了分析，在大队列的妇女：身高，体重，腰围，臀围，多毛症评分，家族史，血清性激素水平，血糖水平，胰岛素水平，血脂level.Intervention（S）：口服葡萄糖耐量试验和胰岛素释放试验进行了每名妇女。观察两组患者的身高、体重、腰围、臀围、Ferriman-Gallwey多毛症分级、性激素水平、血脂水平、血糖耐量、胰岛素水平、家族史等指标。年龄、身高、体重、腰围、臀围、FSH、LH、PRL、E2、各时刻血糖、各时刻胰岛素等指标组间差异无统计学意义。与A组相比，B组的多毛症评分（6.31 ± 6.44 vs. 4.18 ± 4.96）和血清T水平（80.71 ± 17.89 vs. 66.35 ± 33.31）显著更高。B组的胆固醇（4.99 +/- 1.01 vs. 4.70 +/- 0.91）和低密度脂蛋白（3.59 +/- 1.17 vs. 3.03 +/- 1.10）均显著高于A组。B组患者一级亲属糖尿病和高血压的发生率明显高于A组。结论：无多囊卵巢的PCOS患者胆固醇和低密度脂蛋白水平较高，远期并发症的发生率可能较高。
Objective: To demonstrate clinical features of a patient subgroup presenting with polycystic ovary syndrome (PCOS) without polycystic ovary morphology.Design: Retrospective study.Setting: Hospital-based IVF center.Patient(s): In the present study, 876 PCOS patients were selected from women who visited the Reproductive Medicine Center at Shandong Provincial Hospital, Shandong University, between September 2004 and October 2006. Women with PCOS were divided into two groups based on ultrasound image: group A, PCOS patients with classic polycystic ovary (n = 800); group B, PCOS patients without polycystic ovary morphology (n = 76). The following available data were analyzed in the large cohort of women: body height, weight, waistline, hip circumference, hirsutism scores, family history, serum sex hormone levels, blood glucose levels, insulin levels, and blood lipid levels.Intervention(s): An oral glucose tolerance test and insulin release test were performed for each woman. After overnight fasting, blood samples were collected to determine fasting blood glucose, LH, FSH, T, PRL, E-2, and blood lipid levels.Main Outcome Measure(s): Height, weight, waistline, hip circumference, Ferriman-Gallwey grade for hirsutism, gonadal hormone results, blood lipid level, blood glucose tolerance, each-moment insulin level, and family history were determined for the two groups.Result(s): No statistical difference was observed between groups in age, body height and weight, waistline, hip circumference, FSH, LH, PRL, E-2, each-moment blood glucose, and each-moment insulin. There were significantly higher hirsutism scores (6.31 +/- 6.44 vs. 4.18 +/- 4.96) and serum T levels (80.71 +/- 17.89 vs. 66.35 +/- 33.31) in group B than in group A. Cholesterol (4.99 +/- 1.01 vs. 4.70 +/- 0.91) and low-density lipoprotein (3.59 +/- 1.17 vs. 3.03 +/- 1.10) were both significantly higher in group B than in group A. In addition, significantly higher rates of diabetes mellitus and hypertension were observed in patients' first-grade relatives in group B than in group A.Conclusion(s): Patients with PCOS without polycystic ovaries had higher cholesterol and low-density lipoprotein and possibly had a higher incidence of developing long-term complications.