SERUM AMYLOID-A (SAA) VARIATIONS IN PATIENTS WITH CANCER - CORRELATION WITH DISEASE-ACTIVITY, STAGE, PRIMARY SITE, AND PROGNOSIS
SERUM AMYLOID-A (SAA) VARIATIONS IN PATIENTS WITH CANCER - CORRELATION WITH DISEASE-ACTIVITY, STAGE, PRIMARY SITE, AND PROGNOSIS
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DOI：
10.1136/jcp.39.7.794
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发表时间：
1986-07-01
影响因子：
3.4
通讯作者：
SHAINKINKESTENBAUM, R
中科院分区：
文献类型：
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作者：
BIRAN, H;FRIEDMAN, N;SHAINKINKESTENBAUM, R
在 160 名癌症患者中测定了血清淀粉样蛋白 A (SAA)。与非活动状态下的滴度相比，活动性疾病与高滴度相关（分别为31.8 vs 5.8 μg/ml；p = 0.0002）。 SAA值与疾病分期直接相关：1期和2期最低，4期转移最高（1 v 4期，p = 0.001；2 v 3期，p = 0.05）。肺癌和原发部位不明的癌症的特点是 SAA 浓度高度升高。 初始SAA值具有预后意义：低于10μg/ml的值与生存优势相关，而较高的初始值表明较差结果的可能性更大（精算生存分析p<0.001）。当考虑分期时，初始 SAA 值对晚期疾病患者（3 期和 4 期）的生存具有显着的预后影响，但对局限性疾病患者（1 期和 2 期）的生存没有显着影响。系列测试显示 SAA 滴度变化与临床病程之间具有良好的一致性。
Serum amyloid A (SAA) was determined in 160 patients with cancer. Active disease was associated with high titre compared with the titre in non-active condition (31.8 v 5.8 .mu.g/ml, respectively; p = 0.0002). SAA value showed a direct correlation with the stage of the disease: it was lowest at stages 1 and 2 and highest at the metastatic stage 4(stage 1 v 4, p = 0.001; stage 2 v 3, p = 0.05). Cancers of the lung and unknown primary site were characterised by highly increased SAA concentration. Initial SAA value had prognostic significance: a value below 10 .mu.g/ml correlated with survival advantage, whereas a higher initial value indicated a greater likelihood of a poor outcome (actuarial survival analysis p < 0.001). When stage was accounted for, initial SAA value had significant prognostic bearing on survival of patients with advanced disease (stage 3 and 4) but not on that of patients with limited disease (stages 1 and 2). Serial testing showed good concordance between changes in SAA titre and clinical course.