Phytoestrogens and breast cancer
Phytoestrogens and breast cancer
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DOI：
10.1016/s0960-0760(02)00273-x
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发表时间：
2002-12-01
影响因子：
4.1
通讯作者：
Adlercreutz, H
中科院分区：
文献类型：
--
作者：
Adlercreutz, H
植物雌激素的作用和消费的植物雌激素丰富的食物，如大豆含有黄酮和全谷物产品与木脂素预防乳腺癌的审查。它的结论是，大豆在成年女性的饮食是没有或只有轻微的保护乳腺癌方面，但它可能是有益的，如果消费在青春期前或青春期支持移民和流行病学研究结果的早期生活。没有观察到大豆对乳腺癌的负面影响。另一方面，在病例对照和前瞻性研究中，低木脂素饮食导致低血浆肠内酯浓度增加风险，但也获得了一些有争议的结果。其中一些结果可能是由于不同国家血浆或尿液肠内酯浓度的决定因素非常不同。在斯堪的纳维亚半岛，主要的决定因素是全麦谷物食品，蔬菜和浆果。这种保护作用是否是由饮食中的植物雌激素引起的，或者它们是否只是健康饮食的生物标志物还没有确定。(C)2003爱思唯尔科技有限公司版权所有。
The role of phytoestrogens and consumption of phytoestrogen-rich foods such as soy containing isoflavones and whole grain products with lignans for the prevention of breast cancer is reviewed. It is concluded that soy-containing diet in adult women is not or only slightly protective with regard to breast cancer, but that it may be beneficial if consumed in early life before puberty or during adolescence supporting results of immigrant and epidemiological studies. No negative effects of soy on breast cancer have been observed. On the other hand, a diet low in lignans, resulting in a low plasma enterolactone concentration, increases risk both in a case-control and a prospective study, but some controversial results have also been obtained. Some of these results may be explained by the fact that the determinants of plasma or urinary enterolactone concentration are very different in different countries. In Scandinavia, the main determinants are whole grain cereal food, vegetables and berries. Whether the protective effect is caused by the phytoestrogens in the diet or whether they are only biomarkers of a healthy diet has not been established. (C) 2003 Elsevier Science Ltd. All rights reserved.