Brain activation in PTSD in response to trauma-related stimuli
Brain activation in PTSD in response to trauma-related stimuli
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DOI：
10.1016/s0006-3223(98)00246-7
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发表时间：
1999-04-01
影响因子：
10.6
通讯作者：
Fig, LM
中科院分区：
文献类型：
--
作者：
Liberzon, I;Taylor, SF;Fig, LM
背景：创伤记忆的重复回忆和慢性间歇性过度觉醒是创伤后应激障碍（PTSD）的特征。过度觉醒和记忆功能障碍涉及“边缘”大脑区域，包括杏仁复合体、海马结构和边缘皮层，例如眶额和前扣带回区域。为了研究这些大脑区域在 PTSD 中的神经生物学作用，我们在症状激发范式中使用单光子发射计算机断层扫描 (SPECT) 测量了 PTSD 中的局部脑血流量。方法：对 14 名患有 PTSD 的越南退伍军人、11 名战斗对照受试者和 14 名正常对照受试者进行了两次为期 48 小时的 [Tc-99m] HMPAO 研究 分开：一次是在暴露于白噪音之后，另一次是在暴露于战斗声音之后。研究时记录了皮肤电导、心率和主观体验。结果：所有三组的激活均发生在前扣带回/中前额回。仅在 PTSD 患者中发现左侧杏仁核/伏核区域的激活。在所有三组中均发现左侧压后区域失活。结论：这些发现涉及“边缘”大脑区域，该区域可能介导健康个体和患有创伤后应激障碍（PTSD）的患者对厌恶刺激的反应。 (C) 1999 年生物精神病学协会。
Background: Repetitive recall of traumatic memories and chronic intermittent hyperarousal are characteristic of posttraumatic stress disorder (PTSD). Hyperarousal and memory dysfunction implicates "limbic" brain regions, including the amygdaloid complex, hippocampal formation, and limbic cortex, such as the orbitofrontal and anterior cingulate areas. To investigate the neurobiologic role of these brain regions in PTSD, we measured regional cerebral blood flow in PTSD with single photon emission computerized tomography (SPECT) during a symptom provocation paradigm.Methods: Fourteen Vietnam veterans with PTSD, 11 combat control subjects, and 14 normal control subjects were studied with [Tc-99m] HMPAO in two sessions 48 hours apart: one session after exposure to white noise and the other following exposure to combat sounds. Skin conductance, heart rate, and subjective experience were recorded at the time of the studies.Results: Activation for all three groups occurred in the anterior cingulate/middle prefrontal gyrus. Activation in the region of the left amygdala/nucleus accumbens was found in PTSD patients only. Deactivation was found in all three groups in the left retrosplenial region.Conclusions: These findings implicate regions of the "limbic" brain, which may mediate the response to aversive stimuli in healthy individuals and in patients suffering from PTSD. (C) 1999 Society of Biological Psychiatry.