Reshaping Cinderella's slipper: the shared epitope hypothesis.
Reshaping Cinderella's slipper: the shared epitope hypothesis.
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DOI：
10.1186/ar1970
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发表时间：
2006
影响因子：
4.9
通讯作者：
Winchester R
中科院分区：
文献类型：
--
作者：
Winchester R
关节炎研究和治疗的问题包含Michou和同事的简洁而优雅的论文，该论文通过根据其结构重新分类RA易感性等位基因的贡献来促进我们对类风湿关节炎（RA）的理解。这一研究可能在我们对RA疾病机制，预测疾病病程和严重程度的概念上以及作为该主题进一步研究的模型中很重要。作者重新评估共享表位的分子结构的方法，将注意力重定向使用，使用与易感性的主要组织相容性复合物分子的结合特性，该分子与探索驱动类风湿性关节炎基础的自身免疫性过程的肽相关的易感性相关。
This issue of Arthritis Research and Therapy contains a succinct and elegant paper by Michou and colleagues that advances our understanding of the genetic basis of rheumatoid arthritis (RA) by reclassifying the contribution of RA susceptibility alleles according to their structure. This line of research is potentially important in our conceptualization of the mechanism of disease in RA, in predicting disease course and severity, and as a model for further studies on this topic. The author's approach to reassessing the molecular structure of the shared epitope redirects attention to using the binding properties of the major histocompatibility complex molecules associated with susceptibility to search for the peptides driving the autoimmune process underlying rheumatoid arthritis