Galanin, Galanin Receptor Subtypes and Depression-Like Behaviour
Galanin, Galanin Receptor Subtypes and Depression-Like Behaviour
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DOI：
10.1007/978-3-0346-0228-0_12
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Ogren, Sven Ove
中科院分区：
文献类型：
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作者：
Kuteeva, Eugenia;Hokfelt, Tomas;Ogren, Sven Ove
抑郁症的病理生理机制尚不清楚，但与大脑单胺能传递紊乱有关。目前的抗抑郁药物通过增强这种类型的神经传递来起作用，对许多患者的治疗效果有限，而且还会产生严重的副作用，这限制了它们的依从性。越来越多的证据表明神经肽，包括甘丙肽，可能与情绪障碍有关。甘丙肽共表达并调节去甲肾上腺素和血清素的传递，两者都与抑郁症有关。药理学和遗传学研究表明，甘丙肽在啮齿类动物的抑郁样行为中起作用，涉及特定受体亚型。因此，刺激GaIR1和/或GaIR3受体会导致抑郁样表型，而激活GaIR2受体会减少大鼠的抑郁样行为。这些发现表明，丙氨酸受体亚型可能是抗抑郁药物开发的新靶点。
The pathophysiology of depression remains unclear, but involves disturbances in brain monoaminergic transmission. Current antidepressant drugs, which act by enhancing this type of neurotransmission, have limited therapeutic efficacy in a number of patients, and also cause serious side-effects, which limits their compliance. Increasing evidence suggests that neuropeptides, including galanin, can be of relevance in mood disorders. Galanin is co-expressed with and modulates noradrenaline and serotonin transmission, both implicated in depression. Pharmacological and genetic studies suggest a role for galanin in depression-like behaviour in rodents, involving specific receptor subtypes. Thus, stimulation of GaIR1 and/or GaIR3 receptors results in depression-like phenotype, while activation of the GaIR2 receptor reduces depression-like behaviour in the rat. These findings suggest that galanin receptor subtypes may represent novel targets for the development of antidepressant drugs.