The art of microRNA: various strategies leading to gene silencing via an ancient pathway.
The art of microRNA: various strategies leading to gene silencing via an ancient pathway.
复制标题
DOI：
10.1016/j.bbagrm.2008.06.006
复制
发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
G. Tang;Xiaoqing Tang;Venugopal Mendu;Xiaohu Tang;Xiaoyun Jia;Qi-Jun Chen;Li-heng He
中科院分区：
文献类型：
--
作者：
G. Tang;Xiaoqing Tang;Venugopal Mendu;Xiaohu Tang;Xiaoyun Jia;Qi-Jun Chen;Li-heng He
MicroRNAs （miRNAs）是一种内源性的约22个核苷酸（nt）的小rna，长期存在于包括人类在内的动植物细胞中，构成了真核生物基因调控的一条古老途径。它们在成熟时结构简单，但携带着大量信息，可以调节高达90%的人类转录组。此外，miRNA的多面性与多种细胞蛋白密切相关，这使其与各种生理和病理过程广泛相关。本文旨在从mirna的生物发生到其一般功能进行简要的研究，并重点介绍了mirna调控靶mrna的工作机制。
MicroRNAs (miRNAs), an endogenous type of small RNAs of ∼22 nucleotides (nt), have long resided in the cells of plants and animals including humans, constituting an ancient pathway of gene regulation in eukaryotes. They have a simple structure in their mature form but carry enormous information that may regulate up to 90% of the human transcriptome. Furthermore, the multi-facets of a miRNA are tightly associated with diverse cellular proteins that make it broadly connected to various physiological and pathological processes. This review aims to examine miRNAs briefly from their biogenesis to their general functions with an emphasis on working mechanisms in regulation of their target mRNAs.