Diversity-Oriented Stereoselective Synthesis of β,γ-Disubstituted tert -Homoallylic Alcohols
Diversity-Oriented Stereoselective Synthesis of β,γ-Disubstituted tert -Homoallylic Alcohols
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β,γ-二取代叔高烯丙醇的多样性定向立体选择性合成
DOI：
10.1021/acs.orglett.5b00084
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发表时间：
2014
期刊：
影响因子：
5.2
通讯作者：
Akira Tsubouchi
中科院分区：
文献类型：
--
作者：
Takeshi Takeda;Sota Amarume;Ippei Sekioka;Akira Tsubouchi
β-(三甲基硅基)烯丙基苯硫醚与二茂钛(II)-1-丁烯络合物和酮连续反应生成具有良好抗选择性的叔基γ-(三甲基硅基)高烯丙醇，它在叔丁醇铜(I)存在下与多种有机卤化物反应得到交叉偶联产物γ取代的高烯丙醇。
The successive treatment of β-(trimethylsilyl)allyl phenyl sulfides with titanocene(II)-1-butene complex and ketones produced tertiary γ-(trimethylsilyl)homoallylic alcohols with goodanti-selectivity, which reacted with a variety of organic halides in the presence of copper(I)tert-butoxide to afford the cross-coupling products, γ-substituted homoallylic alcohols.