Association of myeloperoxidase, homocysteine and high-sensitivity C-reactive protein with the severity of coronary artery disease and their diagnostic and prognostic value
Association of myeloperoxidase, homocysteine and high-sensitivity C-reactive protein with the severity of coronary artery disease and their diagnostic and prognostic value
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DOI：
10.3892/etm.2020.8817
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发表时间：
2020-08-01
影响因子：
2.7
通讯作者：
Wei, Qingmin
中科院分区：
文献类型：
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作者：
Cheng, Minju;Cheng, Minjing;Wei, Qingmin
在本研究中，评估了冠状动脉疾病（CAD）的严重程度与髓过氧化物酶（MPO）、同型半胱氨酸（Hcy）和高敏C反应蛋白（hs-CRP）之间的关联，并确定了它们的诊断和预后价值。共有112名CAD患者[患者组(PG)]和112名到医院体检的健康参与者[对照组(CG)]纳入本研究。比较两组血浆MPO、Hcy、hs-CRP水平。根据动脉造影结果，将患者进一步分为单支血管病变组（SVG）、双支血管病变组（DVG）和多支血管病变组（MVG）。按照Gensini评分标准评价三组Gensini评分。分析MPO、Hcy或hs-CRP表达与PG Gensini评分的相关性。记录并比较患者6个月内的主要不良心血管事件（MACE），并通过受试者操作特征分析确定MPO、Hcy和hs-CRP对MACE的预测值。结果表明，PG中MPO、Hcy和hs-CRP水平高于CG（P
In the present study, the association between the severity of coronary artery disease (CAD) and myeloperoxidase (MPO), homocysteine (Hcy) and high-sensitivity C-reactive protein (hs-CRP) was assessed and their diagnostic and prognostic value was determined. A total of 112 patients with CAD [patient group (PG)] and 112 healthy participants who visited the hospital for physical examinations [control group (CG)] were enrolled in the present study. The plasma levels of MPO, Hcy and hs-CRP were compared between the two groups. According to the arteriography results, the patients were further divided into the single-vessel disease group (SVG), double-vessel disease group (DVG) and multi-vessel disease group (MVG). The Gensini scores of the three groups were evaluated according to the Gensini score standard. The correlations between the expression of MPO, Hcy or hs-CRP and the Gensini score of the PG were analyzed. The patients' major adverse cardiovascular event (MACEs) were recorded over 6 months and compared, and the predictive values of MPO, Hcy and hs-CRP regarding MACEs were determined by receiver operating characteristics analysis. The results indicated that the levels of MPO, Hcy and hs-CRP in the PG were higher than those in the CG (P