Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer.
Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer.
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DOI：
10.18632/oncotarget.9803
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发表时间：
2016-08-16
期刊：
影响因子：
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通讯作者：
Samant RS
中科院分区：
文献类型：
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作者：
Meng E;Shevde LA;Samant RS
DNAJB6也被称为DnaJ的哺乳动物近亲（MRJ），编码DnaJ/Hsp40共伴侣蛋白家族的一个高度保守成员，与Hsp70伴侣蛋白一起起作用。DNAJB6在所有组织中广泛表达，在大脑中检测到较高的表达水平。DNAJB6参与多种细胞功能，从小鼠胎盘发育，减少错误折叠蛋白聚集体的形成和毒性，到神经干细胞的自我更新。DNAJB6的参与涉及多种病理，如亨廷顿氏病、帕金森病、肢带肌营养不良、心肌细胞肥大和癌症。本文综述了DNAJB6剪接异构体在各种病理中的重要作用，并重点介绍了人类DNAJB6在癌症中的新作用及其潜在的分子机制。
DNAJB6 also known as mammalian relative of DnaJ (MRJ) encodes a highly conserved member of the DnaJ/Hsp40 family of co-chaperone proteins that function with Hsp70 chaperones. DNAJB6 is widely expressed in all tissues, with higher expression levels detected in the brain. DNAJB6 is involved in diverse cellular functions ranging from murine placental development, reducing the formation and toxicity of mis-folded protein aggregates, to self-renewal of neural stem cells. Involvement of DNAJB6 is implicated in multiple pathologies such as Huntington's disease, Parkinson's diseases, limb-girdle muscular dystrophy, cardiomyocyte hypertrophy and cancer. This review summarizes the important involvement of the spliced isoforms of DNAJB6 in various pathologies with a specific focus on the emerging roles of human DNAJB6 in cancer and the underlying molecular mechanisms.