Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis.
Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis.
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头孢洛林耐药、达托霉素耐受和异种万古霉素中间甲氧西林耐药金黄色葡萄球菌引起感染性心内膜炎。
DOI：
10.1128/aac.01235-16
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发表时间：
2017
影响因子：
4.9
通讯作者：
Chambers,HenryF
中科院分区：
文献类型：
--
作者：
Nigo,Masayuki;Diaz,Lorena;Carvajal,LinaP;Tran,TrucT;Rios,Rafael;Panesso,Diana;Garavito,JuanD;Miller,WilliamR;Wanger,Audrey;Weinstock,George;Munita,JoseM;Arias,CesarA;Chambers,HenryF
我们报告一例感染性心内膜炎（IE）引起的头孢洛林耐药，达托霉素耐药，和异质性万古霉素中间耐甲氧西林的S。金黄色葡萄球菌（MRSA）。在没有药物暴露的情况下出现了对头孢洛林的耐药性，并且鉴定了先前与头孢洛林耐药性相关的PBP2a活性位点中的E447K取代。此外，我们目前的证据表明，病人到病人传播的应变在同一单位。该病例说明了在多重耐药表型的情况下治疗MRSA IE的困难。
We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant S. aureus (MRSA). Resistance to ceftaroline emerged in the absence of drug exposure, and the E447K substitution in the active site of PBP2a previously associated with ceftaroline resistance was identified. Additionally, we present evidence of patient-to-patient transmission of the strain within the same unit. This case illustrates the difficulties in treating MRSA IE in the setting of a multidrug-resistant phenotype.