Global Burden of Thrombosis Epidemiologic Aspects
Global Burden of Thrombosis Epidemiologic Aspects
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DOI：
10.1161/circresaha.115.306841
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发表时间：
2016-04-29
影响因子：
20.1
通讯作者：
Raskob, Gary E.
中科院分区：
文献类型：
--
作者：
Wendelboe, Aaron M.;Raskob, Gary E.
据估计，2010年全球每4例死亡中就有1例是血栓栓塞性疾病，是死亡的主要原因。血栓栓塞性疾病分为动脉和静脉血栓性疾病。缺血性心脏病和缺血性中风包括主要的动脉血栓形成，深静脉血栓形成和肺栓塞包括静脉血栓栓塞。房颤是中风和全身动脉血栓栓塞的主要危险因素。全球疾病负担的估计值来自全球疾病负担项目报告、最近的系统性综述，以及检索已发表文献中报告发病率、负担和残疾调整生命年指标的最近研究。每种疾病的全球发病率（IR）估计值为：缺血性心脏病，IR=1518.7;心肌梗死，IR=139.3;缺血性卒中，IR=114.3;房颤，男性IR=77.5，女性IR = 59.5;静脉血栓栓塞，IR=115 - 269。每种疾病的死亡率（MR）为缺血性心脏病，MR=105.5;缺血性卒中，MR=42.3;房颤，MR=1.7;静脉血栓栓塞，MR=9.4 - 32.3。全球公众对肺栓塞（54%）和深静脉血栓形成（44%）的认识远低于心脏病发作（88%）和中风（85%）。随着时间的推移，这些疾病的发病率和MR在发达国家有所改善，但在发展中国家正在增加。特别是在低收入和中等收入地区，需要加强公共卫生工作，以衡量疾病负担，提高对症状和风险因素的认识，以解决这一发病率和死亡率的主要原因。
Thromboembolic conditions were estimated to account for 1 in 4 deaths worldwide in 2010 and are the leading cause of mortality. Thromboembolic conditions are divided into arterial and venous thrombotic conditions. Ischemic heart disease and ischemic stroke comprise the major arterial thromboses and deep-vein thrombosis and pulmonary embolism comprise venous thromboembolism. Atrial fibrillation is a major risk factor for stroke and systemic arterial thromboembolism. Estimates of the global burden of disease were obtained from Global Burden of Disease Project reports, recent systematic reviews, and searching the published literature for recent studies reporting measures of incidence, burden, and disability-adjusted life-years. Estimates per 100 000 of the global incidence rate (IR) for each condition are ischemic heart disease, IR=1518.7; myocardial infarction, IR=139.3; ischemic stroke, IR=114.3; atrial fibrillation, IR=77.5 in males and 59.5 in females; and venous thromboembolism, IR=115 to 269. Mortality rates (MRs) for each condition are ischemic heart disease, MR=105.5; ischemic stroke, MR=42.3; atrial fibrillation, MR=1.7; and venous thromboembolism, MR=9.4 to 32.3. Global public awareness is substantially lower for pulmonary embolism (54%) and deep-vein thrombosis (44%) than heart attack (88%) and stroke (85%). Over time, the incidence and MRs of these conditions have improved in developed countries, but are increasing in developing countries. Public health efforts to measure disease burden and increase awareness of symptoms and risk factors need to improve, particularly in low-and middle-income regions to address this leading cause of morbidity and mortality.