Interleukin-17A-mediated alleviation of cortical astrocyte ischemic injuries affected the neurological outcome of mice with ischemic stroke
Interleukin-17A-mediated alleviation of cortical astrocyte ischemic injuries affected the neurological outcome of mice with ischemic stroke
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白细胞介素-17A-介导的皮质星形胶质细胞缺血性损伤的缓解影响缺血性中风小鼠的神经系统结果
DOI：
10.1002/jcb.28429
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发表时间：
2019-07-01
影响因子：
4
通讯作者：
Li, Junfa
中科院分区：
文献类型：
--
作者：
Dai, Qingqing;Li, Shujuan;Li, Junfa
我们先前报道，星形胶质细胞是产生白介素17A的主要来源，而白介素17A的产生可能加重缺血性卒中的神经元损伤。然而，IL-17A对缺血星形胶质细胞本身的影响及其潜在的分子机制仍不清楚。在本研究中，我们发现重组小鼠(RM)IL-17A能显著(P
We previously reported that astrocytes are the main sources of interleukin (IL)-17A production that could aggravate neuronal injuries in ischemic stroke. However, the effects of IL-17A on ischemic astrocytes themselves and the underlying molecular mechanism are still unclear. In this study, we found that recombinant mouse (rm) IL-17A could significantly (P