Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats
Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats
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DOI：
10.1080/10284150400020482
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发表时间：
2004-10-01
影响因子：
3.6
通讯作者：
Joseph, JA
中科院分区：
文献类型：
--
作者：
Casadesus, G;Shukitt-Hale, B;Joseph, JA
在衰老过程中，海马神经发生的减少与记忆力下降有关，表明存在因果关系。事实上，胰岛素样生长因子-1（IGF-1）是细胞外受体激酶途径的主要激活剂，在学习和记忆过程中起重要作用，也是海马神经发生的关键调节剂。以前，我们发现，与年龄相关的空间记忆任务下降可以通过含有蓝莓的富含抗氧化剂的饮食来改善。在本研究中，为了开始了解蓝莓有益作用的机制，我们评估了补充蓝莓的老年动物海马可塑性参数的变化，如海马神经发生、细胞外受体激酶激活以及IGF-1和IGF-1 R水平。我们的研究结果表明，所有这些参数的海马神经元可塑性增加补充动物和方面，如增殖，细胞外受体激酶激活和IGF-1和IGF-1 R水平与空间记忆的改善。因此，富含多酚的水果（如蓝莓）所提供的认知改善似乎部分是通过其对海马可塑性的影响来介导的。
During aging, reductions in hippocampal neurogenesis are associated with memory decline indicating a causal relationship. Indeed, insulin-like growth factor-1 (IGF-1), a major activator of the extracellular receptor kinase pathway that is central in learning and memory processes, is also a key modulator of hippocampal neurogenesis. Previously, we showed that age-related declines in spatial memory tasks can be improved by antioxidant-rich diets containing blueberries. In this study, to begin to understand the mechanisms responsible for the beneficial effects of blueberries, we assessed changes in hippocampal plasticity parameters such as hippocampal neurogenesis, extracellular receptor kinase activation, and IGF-1 and IGF-1R levels in blueberry-supplemented aged animals. Our results show that all these parameters of hippocampal neuronal plasticity are increased in supplemented animals and aspects such as proliferation, extracellular receptor kinase activation and IGF-1 and IGF-1R levels correlate with improvements in spatial memory. Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity.