The efficacy of extended metacognitive training for psychosis: A randomized controlled trial
The efficacy of extended metacognitive training for psychosis: A randomized controlled trial
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DOI：
10.1016/j.schres.2019.08.006
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发表时间：
2020-01-01
影响因子：
4.5
通讯作者：
Hosono, Masahito
中科院分区：
文献类型：
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作者：
Ishikawa, Ryotaro;Ishigaki, Takuma;Hosono, Masahito
本研究通过一项多中心随机对照试验，研究了10模块元认知训练(MCT)对日本精神分裂症患者的疗效，以测试最新版本和扩展版本的MCI‘对阳性症状的影响。在“照常治疗”(TAU)和TAU+MCT之间进行了一项六中心、随机、评估者盲的对照试验。入选精神分裂症、分裂型和妄想性障碍(ICD10)住院和门诊患者50例，随机分为TAU组(n=26)和TAU+MCT组(n=24)。在基线、6周后、治疗后即刻和治疗后1个月进行评估。主要结果是阳性症状评分，由阳性和阴性症状量表(PANSS)衡量。一般功能评估(GAF)和认知偏差的测量是次要结果。治疗后(10周后)和1个月随访完成率高，TAU+MCT，n=22(91.67%)，TAU，n=23(88.46%)。与TAU组相比，TAU+MCT治疗组PANSS阳性症状的严重程度明显降低。与TAU组相比，TAU+MCT组的GAF也有显著改善。也有一种趋势，即MCT对认知偏见的效果更好。总而言之，这项研究支持了10个模块MCT关于阳性症状(特别是妄想)和一般功能的有效性。(C)2019爱思唯尔B.V.保留所有权利。
This study investigated the efficacy of 10-module metacognitive training (MCT) among Japanese patients with schizophrenia by conducting a multicenter randomized controlled trial to test the influence of the most recent and extended version of MCI' on positive symptoms. A six-center, randomized, assessor-blind, controlled trial between "treatment as usual" (TAU) and TAU + MCT was conducted. Fifty inpatients and outpatients with schizophrenia, schizo-typal, and delusional disorders (ICD 10) were enrolled, then randomly assigned to TAU (n = 26) or TAU + MCT ( n = 24). Assessments were made at baseline, after six weeks, immediately posttreatment, and 1-month post-treatment. The primary outcome was positive symptom score, as measured by the Positive and Negative Syndrome Scale (PANSS). General assessment of functioning (GAF) and measures of cognitive biases were secondary outcomes. Completion at post-treatment (10 weeks later) and 1-month follow-up was high-TAU + MCT, n = 22 (91.67%) and TAU, n = 23 (88.46%). The severity of PANSS positive symptoms declined significantly in the TAU + MCT treatment group compared with the TAU group. GAF also showed significantly greater improvement in the TAU + MCT group compared with the TAU group. There was also a trend for greater efficacy of MCT on cognitive biases. In conclusion, this study provides support for the efficacy of 10 module MCT concerning positive symptomatology (especially, delusion) and general functioning. (C) 2019 Elsevier B.V. All rights reserved.