Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial
Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial
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DOI：
10.3945/ajcn.111.022590
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发表时间：
2012-02-01
影响因子：
7.1
通讯作者：
Amann-Gassner, Ulrike
中科院分区：
文献类型：
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作者：
Hauner, Hans;Much, Daniela;Amann-Gassner, Ulrike
背景：母亲饮食中的长链多不饱和脂肪酸 (LCPUFA) 的组成可能会影响母亲后代的肥胖风险。目的：我们假设孕妇和哺乳期母亲饮食中 n-6 (omega-6): n-3 (omega-3) LCPUFA 比例的减少可能会预防婴儿在婴儿出生第一年出现膨胀性脂肪组织生长。设计：在一项随机对照试验中，208 名健康孕妇被随机分配从怀孕第 15 周到哺乳期 4 个月进行干预（每天补充 1200 毫克 n-3 LCPUFA，并同时减少花生四烯酸摄入量）或控制饮食。主要结果是通过产后 3-5 天、6 周、4 个月和 12 个月在 4 个身体部位测量皮褶厚度 (SFT) 来估计婴儿脂肪量。次要终点包括腹部皮下和腹膜前脂肪、脂肪分布和儿童生长的超声评估。结果：婴儿在 4 次 SFT 的总和上没有差异。
Background: The composition of long-chain PUFAs (LCPUFAs) in the maternal diet may affect obesity risk in the mother's offspring.Objective: We hypothesized that a reduction in the n-6 (omega-6): n-3 (omega-3) LCPUFA ratio in the diet of pregnant women and breastfeeding mothers may prevent expansive adipose tissue growth in their infants during the first year of life.Design: In a randomized controlled trial, 208 healthy pregnant women were randomly assigned to an intervention (1200 mg n-3 LCPUFAs as a supplement per day and a concomitant reduction in arachidonic acid intake) or a control diet from the 15th wk of pregnancy to 4 mo of lactation. The primary outcome was infant fat mass estimated by skinfold thickness (SFT) measurements at 4 body sites at 3-5 d, 6 wk, and 4 and 12 mo postpartum. Secondary endpoints included sonographic assessment of abdominal subcutaneous and preperitoneal fat, fat distribution, and child growth.Results: Infants did not differ in the sum of their 4 SFTs at