Breadth of protection of the respiratory tract provided by different live-attenuated infectious bronchitis vaccines against challenge with infectious bronchitis viruses of heterologous serotypes
Breadth of protection of the respiratory tract provided by different live-attenuated infectious bronchitis vaccines against challenge with infectious bronchitis viruses of heterologous serotypes
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DOI：
10.1080/03079459994506
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发表时间：
1999-10-01
期刊：
影响因子：
2.8
通讯作者：
Huggins, MB
中科院分区：
文献类型：
--
作者：
Cook, JKA;Orbell, SJ;Huggins, MB
1日龄接种传染性支气管炎(IB)MA5疫苗(马萨诸塞州血清型)，2周龄接种异种4/91疫苗，对无特定病原体的雏鸡呼吸道保护效果显著。通过评估挑战后气管上皮的纤毛活性来衡量保护作用，在5周龄时，用从世界不同地区疾病暴发中分离出的多种血清型的IB菌株，对挑战具有极好的抵抗力。这种疫苗接种方案比第一次接种同一血清型的疫苗更有效，而且当MA5疫苗在4/91疫苗接种之前而不是在4/91疫苗接种的同时或之后接种时，可以看到明显更好的保护。这两种IB疫苗的使用将经常扩大对许多不同血清型IB分离株的攻击的保护，而不需要开发新的IB疫苗来对抗出现的每一种新的IB血清型。
The regime of administering the infectious bronchitis (IB) Ma5 vaccine (Massachusetts serotype) at 1 day old and the heterologous 4/91 vaccine at 2 weeks of age, was shown to be highly effective in protecting the respiratory tract of specified pathogen free chickens. Protection, as measured by assessing ciliary activity of the tracheal epithelium following challenge, was excellent against challenge at 5 weeks of age with IB strains of many serotypes, isolated from disease outbreaks in different parts of the world. This vaccination protocol was more effective than revaccination with a vaccine of the same serotype as the first vaccine, Furthermore, significantly better protection was seen when the Ma5 vaccine was given before, rather than at the same time as or following, the 4/91 vaccine.It is suggested that the use of these two IB vaccines will frequently broaden the protection possible against challenge with IB isolates of many different serotypes, without the need to develop a new IB vaccine to combat each new IB serotype that emerges.