Human T-cell lymphotropic virus type 1-transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells
Human T-cell lymphotropic virus type 1-transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells
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DOI：
10.1182/blood.v99.9.3383
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发表时间：
2002-05-01
期刊：
影响因子：
20.3
通讯作者：
Bazarbachi, A
中科院分区：
文献类型：
--
作者：
El-Sabban, ME;Abou Merhi, R;Bazarbachi, A
血管生成在实体瘤生长和转移中的作用已得到证实。然而，血管生成在血液恶性肿瘤中的作用直到最近才被认识到。我们发现htlv -1转化的T细胞，而不是htlv -1阴性的CD4(+) T细胞，分泌具有生物活性的血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF），并因此在体外诱导血管生成。此外，来自急性ATL患者的新鲜ATL白血病细胞产生VEGF和bFGF转录物和蛋白质。病毒反激活因子Tax激活VEGF启动子，将血管生成的诱导与病毒基因表达联系起来。血管生成与htlv -1转化细胞与内皮细胞的粘附以及间隙连接介导的两种细胞间的异细胞通讯有关。血管生成、细胞粘附和通讯可能有助于成人t细胞白血病淋巴瘤的发展，并代表潜在的治疗靶点。(C) 2002年由美国血液病学会出版。
The role of angiogenesis in the growth and metastasis of solid tumors is well established. However, the role of angiogenesis in hematologic malignancies was only recently appreciated. We show that HTLV-1-transformed T cells, but not HTLV-1-negative CD4(+) T cells, secrete biologically active forms of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and, accordingly, induce angiogenesis in vitro. Furthermore, fresh ATL leukemic cells derived from patients with acute ATL produce VEGF and bFGF transcripts and proteins. The viral transactivator Tax activates the VEGF promoter, linking the induction of angiogenesis to viral gene expression. Angiogenesis is associated with the adhesion of HTLV-1-transformed cells to endothelial cells and gap junction-mediated heterocellular communication between the 2 cell types. Angiogenesis, cell adhesion, and communication likely contribute to the development of adult T-cell leukemia-lymphoma and represent potential therapeutic targets. (C) 2002 by The American Society of Hematology.