Organocatalytic One-Pot Asymmetric Synthesis of 2-Aryl-2,3-dihydro-4-quinolones.
Organocatalytic One-Pot Asymmetric Synthesis of 2-Aryl-2,3-dihydro-4-quinolones.
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DOI：
10.1002/chin.201630179
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
Gao-Fei Pan;Lianzheng Su;Yan-Lei Zhang;Shi‐Huan Guo;Yong-Qiang Wang
中科院分区：
文献类型：
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作者：
Gao-Fei Pan;Lianzheng Su;Yan-Lei Zhang;Shi‐Huan Guo;Yong-Qiang Wang
以邻氨基苯乙酮和芳基醛为原料，进行了高效的一锅对映选择性有机催化合成(R)-2-芳基-2,3-二氢-4-喹诺酮。该方法的特点是不含金属、不含溶剂、不含保护基团。以99%的收率可制得多种2-芳基-2,3-二氢-4-喹诺酮类化合物。
A highly efficient organocatalytic one-pot enantioselective synthesis of (R)-2-aryl-2,3-dihydro-4-quinolones from o-aminoacetophenones and aryl aldehydes has been developed. The approach is characterized by being metal free, solvent free and protecting group free. A variety of 2-aryl-2,3-dihydro-4-quinolones could be obtained in good yields up to 99% ee.