Local GABA circuit control of experience-dependent plasticity in developing visual cortex
Local GABA circuit control of experience-dependent plasticity in developing visual cortex
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DOI：
10.1126/science.282.5393.1504
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发表时间：
1998-11-20
期刊：
影响因子：
56.9
通讯作者：
Kash, SF
中科院分区：
文献类型：
--
作者：
Hensch, TK;Fagiolini, M;Kash, SF
早期生命的感官体验塑造了哺乳动物的大脑。在一个小鼠模型中，研究人员发现了发育中的视觉皮层中依赖活动的功能连接的细化受损。在体外实验中，基因靶向破坏谷氨酸脱羧酶的一种异构体，可以防止对短暂视力丧失的眼睛的竞争性反应丧失，而不影响突触修饰的合作机制。苯二氮卓类药物选择性地、药物依赖地增强皮质内快速抑制传递，在体内恢复可塑性，挽救遗传缺陷。视觉皮层固有的抑制性中间神经元的特定网络可能检测到感官输入的扰动，从而在发育过程中驱动经验依赖的可塑性。
Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model. Gene-targeted disruption of one isoform of glutamic acid decarboxylase prevented the competitive loss of responsiveness to an eye briefly deprived of vision, without affecting cooperative mechanisms of synapse modification in vitro. Selective, use-dependent enhancement of fast intracortical inhibitory transmission with benzodiazepines restored plasticity in vivo, rescuing the genetic defect. Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development.