BLOOD OXYGEN-AFFINITY AND ALVEOLAR VENTILATION IN RELATION TO BODY-WEIGHT IN MAMMALS
BLOOD OXYGEN-AFFINITY AND ALVEOLAR VENTILATION IN RELATION TO BODY-WEIGHT IN MAMMALS
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DOI：
10.1152/ajplegacy.1975.229.2.529
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发表时间：
1975-01-01
影响因子：
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通讯作者：
LAHIRI, S
中科院分区：
文献类型：
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作者：
LAHIRI, S
本文以血液pH值为固定变量，重新检验了恒温哺乳动物血氧亲和力和肺泡通气量与体重之间关系的概念的有效性。通过体外平衡技术，在37 ℃下测定了各种恒温哺乳动物在pH 7.4下50%饱和度的血液Po 2（P50（7.4））和在pH 7.4下氧合血液的PCO 2（PCO 2（7.4））。在某些物种中，还测量了动脉PCO 2、PO 2和pH值。PCO 2（7.4）与动脉PCO 2相似，在28- 100，000 g范围内与体重的相关系数为+0.33，在200 g以下的物种中为+0.90。所有物种的P50（7.4）值范围为26.0 - 38.7 mmHg，与体重相关性不好（r = -0.43）。对于小型哺乳动物（小于200 g），相关系数为-0.91。体温和动脉pH下的体内P50虽然与P50（7.4）不同，但与体重显示出类似的相关性。缺乏有效的概括表明，体重只是影响O2运输系统的复合因素之一。
The validity of the concept relating blood oxygen affinity and alveolar ventilation to body weight in homeothermic mammals was reexamined with blood pH used as the fixed variable. Blood Po2 at 50% saturation at pH 7.4 (P50(7.4)) and PCO2 of oxygenated blood at pH 7.4 (PCO2(7.4)) from a variety of homeothermic mammals were determined at 37 degrees C by in vitro equilibration techniques. In some species, arterial PCO2, PO2, and pH were also measured. PCO2(7.4), which was similar to arterial PCO2, showed a correlation coefficient of +0.33 with body weight over the range of 28-100,000 g and +0.90 among the species under 200 g. P50(7.4) values, which ranged from 26.0 to 38.7 mmHg for all the species, were not well correlated (r = -0.43) with body weight. For the small mammals (less than 200 g) the correlation coefficient was -0.91. In vivo P50 at the body temperature and arterial pH, although different from P50(7.4), showed a similar correlation with body weight. The lack of valid generalization suggests that body weight is only one of the composite factors that influence O2 transport systems.