ROLE OF MATERNAL ANTIBODY IN PNEUMONIA AND BRONCHIOLITIS DUE TO RESPIRATORY SYNCYTIAL VIRUS
ROLE OF MATERNAL ANTIBODY IN PNEUMONIA AND BRONCHIOLITIS DUE TO RESPIRATORY SYNCYTIAL VIRUS
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DOI：
10.1093/infdis/134.3.211
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发表时间：
1976-01-01
影响因子：
6.4
通讯作者：
MUFSON, MA
中科院分区：
文献类型：
--
作者：
LAMPRECHT, CL;KRAUSE, HE;MUFSON, MA
本文对15例呼吸道合胞病毒（RSV）肺炎患儿和19例呼吸道合胞病毒引起的毛细支气管炎患儿进行了同源循环中和抗体对其病情严重程度的影响研究。所有婴儿年龄均在9岁以下。虽然母体中和抗体不能预防RSV感染和疾病，但中和抗体水平与RSV引起的肺炎严重程度呈负相关。RSV所致细支气管炎的严重程度与母体抗体水平无关。胸部x线片显示肺炎比毛细支气管炎略严重。疾病的严重程度和母体中和抗体的存在与补体固定抗体的产生无关。
Fifteen infants with pneumonia caused by respiratory syncytial virus (RSV) and 19 infants with bronchiolitis caused by RSV were studied for the influence of homologous, circulating neutralizing antibody on the severity of their illness. All infants were under 9 mo. old. Although maternal neutralizing antibody did not prevent infection with RSV and illness, the severity of pneumonia caused by RSV was inversely related to the level of neutralizing antibody. The severity of bronchiolitis caused by RSV was unrelated to maternal antibody levels. Chest roentgenograms showed pneumonia to be slightly more severe than bronchiolitis. Neither the severity of illness nor the presence of maternal neutralizing antibody was related to the development of complement-fixing antibody.