Percutaneous transluminal coronary angioplasty restenosis: potential prevention with laser balloon angioplasty.
Percutaneous transluminal coronary angioplasty restenosis: potential prevention with laser balloon angioplasty.
复制标题
经皮冠状动脉腔内成形术再狭窄：激光球囊血管成形术的潜在预防。
DOI：
10.1016/0002-9149(87)90487-5
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
J. Spears
中科院分区：
文献类型：
--
作者：
J. Spears
经皮腔内冠状动脉成形术后的再狭窄可能主要是由于血栓形成表面和动脉壁和管腔破裂产生的局部血流分离的结合。弹性回缩和细胞增殖可能进一步导致经皮冠状动脉腔内成形术后管腔受损。激光球囊血管成形术是在常规球囊血管成形术的最后充气期间进行的，它利用Nd：YAG激光辐射的凝固特性将破裂的组织成分热焊接在一起，以减少弹性回缩并破坏有活力的动脉组织。在人体死后动脉粥样硬化和动物模型中的研究表明，激光球囊血管成形术，通过创建一个管腔，近似的大小和光滑的圆柱形的球囊，应该是有效的治疗再狭窄的重要原因。
Restenosis after percutaneous transluminal coronary angioplasty may result primarily from the combination of a thrombogenic surface and local flow separation produced by disruption of the arterial wall and lumen. Elastic recoil and, perhaps, cellular proliferation further contribute to luminal compromise after percutaneous transluminal coronary angioplasty. Laser balloon angioplasty, performed during the final inflation of an otherwise conventional balloon angioplasty procedure, uses the coagulative properties of Nd:YAG laser radiation to weld together disrupted tissue elements thermally, to reduce elastic recoil and to destroy viable arterial tissue. Studies in human postmortem atheromatous arteries and in animal models in vivo indicate that laser balloon angioplasty, by creating a lumen that approximates the size and smooth cylindrical shape of the balloon, should be effective in the treatment of important causes of restenosis.