Intercellular communication in the anterior pituitary.
Intercellular communication in the anterior pituitary.
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DOI：
10.1210/edrv.21.5.0408
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发表时间：
2000-10
影响因子：
20.3
通讯作者：
J. Schwartz;J. Schwartz
中科院分区：
文献类型：
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作者：
J. Schwartz;J. Schwartz
除了下丘脑和反馈输入外，垂体前叶的分泌细胞还受到腺内分泌因子活性的影响。在过去的十年中，假定的垂体内因子的列表一直在稳步扩大，尽管直到最近，大部分工作仅限于描述潜在的相互作用。这表现为垂体内产生已知影响分泌细胞活性的因子的证据，或者进一步描述了外源性添加这些因子对垂体细胞的作用。已经进入了一个新的发现阶段，正在进行广泛的努力，以描绘控制的合成和分泌的垂体内的腺体，调节的受体和反应机制的垂体细胞中的因素，并通过使用特定的免疫中和，受体阻断，组织从转基因动物，和其他手段的测量的内源性行动的因素。总之，这些发现正在产生垂体内相互作用的蓝图，影响每种单独类型的分泌细胞，导致对相互作用的生理意义的理解。本文的目的是回顾最近的文献中的许多因素作为垂体内信号，并提出这样的发现的背景下，分泌细胞的生理。
In addition to hypothalamic and feedback inputs, the secretory cells of the anterior pituitary are influenced by the activity of factors secreted within the gland. The list of putative intrapituitary factors has been expanding steadily over the past decade, although until recently much of the work was limited to descriptions of potential interactions. This took the form of evidence of production within the pituitary of factors already known to influence activity of secretory cells, or further descriptions of actions on pituitary cells by such factors when added exogenously. A new phase of discovery has been entered, with extensive efforts being made to delineate the control of the synthesis and secretion of the pituitary factors within the gland, regulation of the receptors and response mechanisms for the factors in pituitary cells, and measurements of the endogenous actions of the factors through the use of specific immunoneutralization, receptor blockade, tissue from transgenic animals, and other means. Taken together, these findings are producing blueprints of the intrapituitary interactions that influence each of the individual types of secretory cells, leading toward an understanding of the physiological significance of the interactions. The purpose of this article is to review the recent literature on many of the factors acting as intrapituitary signals and to present such finding in the context of the physiology of the secretory cells.