Electroacupuncture prevents cognitive impairments by regulating the early changes after brain irradiation in rats.
Electroacupuncture prevents cognitive impairments by regulating the early changes after brain irradiation in rats.
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电针通过调节大鼠脑部照射后的早期变化来预防认知障碍
DOI：
10.1371/journal.pone.0122087
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wu KL
中科院分区：
文献类型：
--
作者：
Fan XW;Chen F;Chen Y;Chen GH;Liu HH;Guan SK;Deng Y;Liu Y;Zhang SJ;Peng WJ;Jiang GL;Wu KL
认知障碍严重影响接受脑放射治疗的患者的生活质量，并且没有有效的预防策略。在这项研究中，我们研究了电针（EA）的治疗潜力后立即给予脑照射大鼠。我们检测了照射后不同时间点的认知功能、神经发生和突触密度的变化，但发现EA可以保护血脑屏障（BBB），抑制神经炎性细胞因子的表达，上调血管生成细胞因子的表达，并在早期调节神经递质受体和神经肽的水平。电针对延迟相的空间记忆和再认有保护作用。在细胞/分子水平上，EA对认知功能障碍的预防作用不依赖于海马神经发生;相反，它与突触素表达有关。我们的研究结果表明，EA适用于脑照射后立即可以防止认知功能障碍，通过保护对辐射引起的早期变化，并可能是一种新的方法，用于预防或改善认知功能障碍的脑肿瘤患者谁需要放疗。
Cognitive impairments severely affect the quality of life of patients who undergo brain irradiation, and there are no effective preventive strategies. In this study, we examined the therapeutic potential of electroacupuncture (EA) administered immediately after brain irradiation in rats. We detected changes in cognitive function, neurogenesis, and synaptic density at different time points after irradiation, but found that EA could protect the blood-brain barrier (BBB), inhibit neuroinflammatory cytokine expression, upregulate angiogenic cytokine expression, and modulate the levels of neurotransmitter receptors and neuropeptides in the early phase. Moreover, EA protected spatial memory and recognition in the delayed phase. At the cellular/molecular level, the preventative effect of EA on cognitive dysfunction was not dependent on hippocampal neurogenesis; rather, it was related to synaptophysin expression. Our results suggest that EA applied immediately after brain irradiation can prevent cognitive impairments by protecting against the early changes induced by irradiation and may be a novel approach for preventing or ameliorating cognitive impairments in patients with brain tumors who require radiotherapy.
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DOI：
10.1158/1078-0432.ccr-08-1420
发表时间：
2009-03-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Cao Y;Tsien CI;Sundgren PC;Nagesh V;Normolle D;Buchtel H;Junck L;Lawrence TS
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DOI：
10.1158/1078-0432.ccr-11-2903
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2013-05-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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作者：
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通讯作者：
Robbins ME
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
5
作者：
ALAOUI, F;PRATT, J;STUTZMANN, JM
通讯作者：
STUTZMANN, JM
影响因子：
9.3
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