Global genetic structure and molecular epidemiology of encapsulated Haemophilus influenzae.
Global genetic structure and molecular epidemiology of encapsulated Haemophilus influenzae.
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封装流感嗜血杆菌的全球遗传结构和分子流行病学。
DOI：
10.1093/clinids/12.1.75
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Hammond,G
中科院分区：
文献类型：
--
作者：
Musser,JM;Kroll,JS;Granoff,DM;Moxon,ER;Brodeur,BR;Campos,J;Dabernat,H;Frederiksen,W;Hamel,J;Hammond,G
收集了6种多糖囊型流感嗜血杆菌的2,209个分离株，其中包括在30个国家回收的1,975个b型分离株，在17个代谢酶座位上进行了电泳性等位基因分析。共鉴定出280个不同的多位点基因型别，聚类分析显示有两个初步的系统发育分化。微囊化的H。流感病毒具有克隆性。目前，世界上大多数侵袭性疾病是由9个克隆的b型毒株引起的，产生c、e和f型衣壳的毒株属于单科，与其他血清型的毒株没有密切的亲缘关系，a和b型毒株存在于两个主要的系统发育区段，可能是由于克隆谱系之间的血清型特异性片段序列的转移和重组所致。D型分离株与一些a、b型分离株之间存在着密切的遗传关系，在洲际尺度上，无论是遗传多样性的大小还是被囊化菌株群体的克隆组成，都有很强的地理变异模式。分析表明，目前克隆的分布部分与人类宿主群体的种族或民族分化模式和历史人口迁徙有关。
A collection of 2,209 isolates of six polysaccharide capsule types ofHaemophilus influenzoe, including 1,975 serotype b isolates recovered in 30 countries was characterized for electrophoretically demonstrable allele profiles at 17 metabolic enzyme loci. Two hundred eighty distinct multilocus genotypes were distinguished, and cluster analysis revealed two primary phylogenetic divisions. The population structure of encapsulatedH. influenzaeis clonal. Currently, most of the invasive disease worldwide is caused by serotype b strains of nine clones, Strains producing serotype c, e, and f capsules belong to single divisions and have no close genetic relationships to strains of other serotypes, Serotype a and b strains occur in both primary phylogenetic divisions, probably as a result of transfer and recombination of serotype-specific sequences of thecapregion between clonal lineages. A close genetic relatedness between serotype d isolates and some strains of serotypes a and b was identified, There are strong patterns of geographic variation, on an intercontinental scale, in both the extent of genetic diversity and the clonal composition of populations of encapsulated strains, The analysis suggests that the present distribution of clones is, in part, related to patterns of racial or ethnic differentiation and historical demographic movements of the human host populations.