Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study.
Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study.
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DOI：
10.1016/j.diabres.2015.10.009
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发表时间：
2015-12
影响因子：
5.1
通讯作者：
Miwa Yamaguchi;H. Uemura;K. Arisawa;S. Katsuura-Kamano;N. Hamajima;A. Hishida;S. Suma;I. Oze;Kazuyo Nakamura;N. Takashima;Sadao Suzuki;R. Ibusuki;H. Mikami;K. Ohnaka;N. Kuriyama;M. Kubo;Hideo Tanaka
中科院分区：
文献类型：
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作者：
Miwa Yamaguchi;H. Uemura;K. Arisawa;S. Katsuura-Kamano;N. Hamajima;A. Hishida;S. Suma;I. Oze;Kazuyo Nakamura;N. Takashima;Sadao Suzuki;R. Ibusuki;H. Mikami;K. Ohnaka;N. Kuriyama;M. Kubo;Hideo Tanaka
目的脑肌肉 Arnt 样蛋白 1 (BMAL1) 和 BMAL2 基因是生物钟的重要组成部分，被认为参与葡萄糖稳态。我们检查了 BMAL1 和 BMAL2 的单核苷酸多态性 (SNP) 是否与日本普通人群中 2 型糖尿病 (T2DM) 的患病率相关。 方法我们研究了来自日本多机构协作队列研究参与者的 2467 名受试者（1232 名男性和 1235 名女性，35-69 岁），其中包括 105 名男性和 57 名女性患有 T2DM。在调整潜在混杂因素后，通过多元逻辑回归分析BMAL1（rs11022775和rs2290035）和BMAL2（rs7958822）基因中的SNP与T2DM之间的关联。按体重指数（≥25 kg/m2 和 <25 kg/m2）分层后还进行了分析，以研究基因型与肥胖之间的相互作用。结果BMAL2rs7958822 的 A/G 和 A/A 基因型在肥胖男性中显示出比 G/G 基因型显着更高的 T2DM 调整优势比 (OR)（OR = 2.2，95% 置信区间 [CI] 1.1、4.6，交互作用 P = 0.0495）和肥胖女性（OR = 2.7，95% CI 1.1、6.7，交互作用 P = 0.199）。 BMAL1rs11022775 或 rs2290035 基因型与 T2DM 之间没有显着关联。结论 据我们所知，这是第一项显示肥胖受试者中 BMAL2rs7958822 基因型与 T2DM 显着关联的研究。
AimsBrain-muscle-Arnt-like protein-1 (BMAL1) andBMAL2genes are essential components of the circadian clock, and are considered to be involved in glucose homeostasis. We examined whether single nucleotide polymorphisms (SNPs) ofBMAL1andBMAL2were associated with the prevalence of type 2 diabetes (T2DM) in the general Japanese population.MethodsWe studied 2467 subjects (1232 men and 1235 women, 35–69 years old), including 105 men and 57 women with T2DM, from the participants of the Japan Multi-institutional Collaborative Cohort Study. The association between SNPs in theBMAL1(rs11022775 and rs2290035) andBMAL2(rs7958822) genes and T2DM were analyzed by multiple logistic regression after adjustment for potential confounders. Analysis was also performed after stratification by body mass index (≥25 kg/m2and <25 kg/m2) to investigate an interaction between genotypes and obesity.ResultsThe A/G and A/A genotypes ofBMAL2rs7958822 showed significantly higher adjusted odds ratios (OR) for T2DM than the G/G genotype among obese men (OR = 2.2, 95% confidence intervals [CI] 1.1, 4.6,Pfor interaction = 0.0495) and obese women (OR = 2.7, 95% CI 1.1, 6.7,Pfor interaction = 0.199). There were no significant associations betweenBMAL1rs11022775 or rs2290035 genotypes and T2DM.ConclusionsTo the best of our knowledge, this is the first study to show the significant association betweenBMAL2rs7958822 genotype and T2DM among obese subjects.