Clinical response and outcome of infection with Salmonella enterica serotype typhi with decreased susceptibility to fluoroquinolones:: a United States FoodNet multicenter retrospective cohort study
Clinical response and outcome of infection with Salmonella enterica serotype typhi with decreased susceptibility to fluoroquinolones:: a United States FoodNet multicenter retrospective cohort study
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DOI：
10.1128/aac.01509-07
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发表时间：
2008-04-01
影响因子：
4.9
通讯作者：
Angulo, Frederick J.
中科院分区：
文献类型：
--
作者：
Crump, John A.;Kretsinger, Katrina;Angulo, Frederick J.
由肠沙门氏菌血清型伤寒菌株引起的伤寒患者，其氟喹诺酮类药物的 MIC 升高，但根据临床和实验室标准研究所当前的解释标准被分类为易感人群，可能对氟喹诺酮类药物治疗没有充分反应。 1999 年至 2002 年间来自美国七个州的侵袭性沙门氏菌血清型伤寒感染患者参加了一项多中心回顾性队列研究。将环丙沙星 MIC 为 0.12 至 1 μg/ml 的伤寒沙门氏菌血清型分离株感染患者（环丙沙星敏感性降低，但对环丙沙星不耐药 [DCS]）与感染环丙沙星 MIC 分离株的患者进行比较
Patients with typhoid fever due to Salmonella enterica serotype Typhi strains for which fluoroquinolones MICs are elevated yet that are classified as susceptible by the current interpretive criteria of the Clinical and Laboratory Standards Institute may not respond adequately to fluoroquinolone therapy. Patients from seven U.S. states with invasive Salmonella serotype Typhi infection between 1999 and 2002 were enrolled in a multicenter retrospective cohort study. Patients infected with Salmonella serotype Typhi isolates with ciprofloxacin MICs of 0.12 to 1 mu g/ml (decreased ciprofloxacin susceptibility but not resistant to ciprofloxacin [DCS]) were compared with patients infected with isolates with ciprofloxacin MICs