Photopolymerizable hydrogels for tissue engineering applications
Photopolymerizable hydrogels for tissue engineering applications
复制标题
DOI：
10.1016/s0142-9612(02)00175-8
复制
发表时间：
2002-11-01
期刊：
影响因子：
14
通讯作者：
West, JL
中科院分区：
文献类型：
--
作者：
Nguyen, KT;West, JL
由于光聚合水凝胶能够以微创方式（例如通过注射）原位形成这些材料，因此正在研究其用于许多组织工程应用。此外，水凝胶，能够溶胀大量水的亲水聚合物的三维网络，可以被制成类似于软组织的物理特性。水凝胶材料通常还表现出高渗透性和良好的生物相容性，这些材料对于用于细胞包封和组织工程应用具有吸引力。许多水凝胶材料可以通过光聚合过程形成，该过程足够温和以在活细胞存在下进行。这允许在整个支架材料中均匀地接种细胞并原位形成水凝胶。本文介绍了水凝胶光聚合的优点，并介绍了目前使用的光引发剂和材料。综述了近年来光聚合水凝胶在组织工程中的应用。(C)2002爱思唯尔科技有限公司版权所有。
Photopolymerized hydrogels are being investigated for a number of tissue engineering applications because of the ability to form these materials in situ in a minimally invasive manner such as by injection. In addition, hydrogels, three-dimensional networks of hydrophilic polymers that are able to swell large amounts of water, can be made to resemble the physical characteristics of soft tissues. Hydrogel materials also generally exhibit high permeability and good biocompatibility making, these materials attractive for use in cell encapsulation and tissue engineering applications. A number of hydrogel materials can be formed via photopolymerization processes mild enough to be carried out in the presence of living cells. This allows one to homogeneously seed cells throughout the scaffold material and to form hydrogels in situ. This review presents advantages of photopolymerization of hydrogels and describes the photoinitiators and materials in current use. Applications of photopolymerized hydrogels in tissue engineering that have been investigated are summarized. (C) 2002 Elsevier Science Ltd. All rights reserved.