Photo-oxygenation inhibits tau amyloid formation
Photo-oxygenation inhibits tau amyloid formation
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DOI：
10.1039/c9cc01728c
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发表时间：
2019-06-04
影响因子：
4.9
通讯作者：
Tomita, Taisuke
中科院分区：
文献类型：
--
作者：
Suzuki, Takanobu;Hori, Yukiko;Tomita, Taisuke
Tau淀粉样蛋白的形成和沉积是阿尔茨海默病发病的原因。特别是，tau蛋白的播种活性通过其在人脑中的繁殖在tau病理的传播中起着重要作用。在这里，我们证明了催化光氧化显著抑制tau种子活性，从而抑制淀粉样蛋白的形成，无论是在体外还是在培养细胞中。
Tau amyloid formation and deposition are responsible for the onset of Alzheimer's disease. In particular, the seeding activity of the tau protein plays an important role in the spreading of tau pathology via its propagation in the human brain. Here we demonstrate that catalytic photo-oxygenation markedly suppresses tau seeding activity, resulting in the inhibition of amyloid formation, both in vitro and in cultured cells.