Characterization of pABVA01, a Plasmid Encoding the OXA-24 Carbapenemase from Italian Isolates of Acinetobacter baumannii
Characterization of pABVA01, a Plasmid Encoding the OXA-24 Carbapenemase from Italian Isolates of Acinetobacter baumannii
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DOI：
10.1128/aac.00178-09
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发表时间：
2009-08-01
影响因子：
4.9
通讯作者：
Rossolini, Gian Maria
中科院分区：
文献类型：
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作者：
D'Andrea, Marco Maria;Giani, Tommaso;Rossolini, Gian Maria
对两株流行病学上不相关的碳青霉烯类耐药鲍曼不动杆菌分离株进行了研究，作为首批产生OXA-24碳青霉烯酶的意大利分离株的代表。两种分离株均为欧洲克隆谱系II，并携带相同的OXA-24编码质粒，命名为pABVA 01。比较分析显示，在pABVA 01中，bla（OXA-24）是DNA模块的一部分，侧翼是与XerC/XerD结合位点同源的保守反向重复序列，在其他不动杆菌质粒中侧翼是不同的DNA模块，这表明通过一种新的位点特异性重组机制进行动员。
Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, bla(OXA-24) was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism.