PULSATILE COSECRETION OF ESTRADIOL AND PROGESTERONE BY THE MIDLUTEAL PHASE CORPUS-LUTEUM - TEMPORAL LINK TO LUTEINIZING-HORMONE PULSES
PULSATILE COSECRETION OF ESTRADIOL AND PROGESTERONE BY THE MIDLUTEAL PHASE CORPUS-LUTEUM - TEMPORAL LINK TO LUTEINIZING-HORMONE PULSES
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DOI：
10.1210/jcem-70-4-990
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发表时间：
1990-04-01
影响因子：
5.8
通讯作者：
YEN, SSC
中科院分区：
文献类型：
--
作者：
ROSSMANITH, WG;LAUGHLIN, GA;YEN, SSC
使用最近定义的分析工具，允许定量和综合评估的脉动活动的两个或两个以上的homrones，我们已经研究了脉冲的雌二醇（E2），孕酮（P4），和LH确定在血液中抽取的时间间隔为24小时，在每个15名妇女在人类月经周期的黄体中期的时间间隔为15分钟的脉冲的巧合。E2和P4脉冲的出现是同时的，因为它们的峰值在零时滞时最大相关（P < 10-4），并且对于E2存在可比较的周期性（13.5 ± 1.5）。0.7脉冲/24 h）和P4（11.2 ±. 0.7脉冲/24 h）。这种E2和P4的偶联提示成熟黄体的共同分泌。这些E2和P4脉冲与LH脉冲显著耦合，P4的滞后时间约为30 min和/或45 min（P = 0.029），E2的滞后时间约为0 min和/或15 min（P = 0.032）。此外，当一起考虑时，LH，E2和P4被发现是三重共脉冲的（P = 0.0066）。 然而，观察到大量的P4和E2的离散脉冲，而没有先行LH脉冲，这表明一定程度的黄体自主性。总之，协调同步脉动垂体和卵巢（黄体）信号可以证明由协调的时间释放LH，E2，和P4在正常的周期性妇女。
Using recently defined analytical tools that permit quantitative and integrated assessments of pulsatile activities of two or more homrones, we have examined the coincidence of pulses of estradiol (E2), progesterone (P4), and LH determined in blood withdrawn at 15-min sampling intervals for a duration of 24 h in each of 15 women during the midluteal phase of the human menstrual cycle. The occurrence of E2 and P4 pulses is simultaneous, as their peaks were maximally correlated at zero time lag (P < 10-4), and there were comparable periodicities for E2 (13.5 .+-. 0.7 pulses/24 h) and P4 (11.2 .+-. 0.7 pulses/24 h). This coupling of E2 and P4 plses suggests cosecretion by the mature corpus luteum. These E2 and P4 pulses are significantly coupled with LH pulses, with a lag time of about 30 min and/or 45 min for P4 (P = 0.029) and 0 min and/or 15 min for E2 (P = 0.032). Further, when considered together, LH, E2, and P4 are found to be triply copulsatile (P = 0.0066). However, significant numbers of discrete pulses of P4 and E2 are observed without antecedent LH pulses, suggesting some degree of corpus luteum autonomy. In conclusion, orchestrated synchrony of pulsatile pituitary and ovarian (corpus luteum) signaling can be demonstrated by the coordinated temporal release of LH, E2, and P4 in normal cycling women.