Eosinophils as antigen-presenting cells in allergic upper airway disease.
Eosinophils as antigen-presenting cells in allergic upper airway disease.
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DOI：
10.1097/aci.0b013e328334f693
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发表时间：
2010-02
影响因子：
2.8
通讯作者：
Weller PF
中科院分区：
文献类型：
--
作者：
Akuthota P;Wang H;Weller PF
嗜酸性粒细胞作为一种复杂的免疫调节细胞，近年来受到越来越多的重视。嗜酸性粒细胞的一个突出的新的免疫调节功能是它们作为抗原呈递细胞（APC）的作用。本综述将研究证据，增强了对嗜酸性粒细胞作为APC的过敏性炎症的背景下，重点适用于过敏性上气道疾病的数据的理解。最近的研究扩展了先前的发现，即嗜酸性粒细胞可以表达MHC II类和共刺激分子。还发现嗜酸性粒细胞可以运输到局部淋巴结，并在各种实验环境中充当专业的APC。越来越多的证据表明，嗜酸性粒细胞作为APC的能力，嗜酸性粒细胞可能有更复杂的免疫调节作用，在过敏性上气道疾病比以前认识。
The recognition of eosinophils as complex immunomodulatory cells has been increasing in recent years. One prominent novel immunomodulatory function of eosinophils is their role as antigen presenting cells (APCs). This review will examine the evidence that has enhanced the understanding of eosinophils as APCs in the context of allergic inflammation, with a focus on data applicable to allergic upper airway disease. Recent studies expand on prior findings that eosinophils can express MHC Class II and co-stimulatory molecules. Eosinophils have also been found to traffic to regional lymph nodes and act as professional APCs in various experimental settings. Accumulating evidence of the ability of eosinophils to act as APCs suggests that eosinophils may have more complex immunomodulatory roles in allergic upper airway disease than previously appreciated.