Red blood cell sodium, potassium, and ATP levels during hemorrhagic shock.
Red blood cell sodium, potassium, and ATP levels during hemorrhagic shock.
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失血性休克期间红细胞钠、钾和 ATP 水平。
DOI：
10.1016/0022-4804(81)90225-0
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Baue,AE
中科院分区：
文献类型：
--
作者：
KreisJr,DJ;Chaudry,IH;Schleck,S;Baue,AE
使用两种休克模型研究了失血性休克和全血输注对红细胞 (RBC) Na+、K+ 和 ATP 水平的影响。 A组动物放血至40毫米汞柱的压力，之后不再取出或返回血液。这些大鼠的血压在 30 分钟内升至约 70 mm Hg，并保持在该水平 2 小时。 B组动物放血至40毫米汞柱的压力并维持在该水平2小时。在受到电击的 A 组动物中，红细胞 Na+ 或 K+ 水平没有发现显着变化。然而，在遭受失血性休克的 B 组动物中观察到红细胞阳离子发生微小但显着的变化。 B 组中，ATP 水平从 1.51 毫摩尔/升红细胞下降至 1.27 毫摩尔/升红细胞。在另一项研究（C 组）中，与 B 组一样对大鼠进行休克，但输入的是在冷 ACD 缓冲液中保存 6 天的大鼠全血，而不是自己流下的血液。 C组红细胞Na+从3.5±0.1上升至8.4±0.7，K+从100.3±2.3下降至85.0±2.1。储存血液本身的红细胞Na+在冷藏3天和6天时分别增加288%和355%。这些结果表明：（1）严重失血性休克导致红细胞Na+和K+水平发生微小变化； (2)先前报道的人类红细胞阳离子水平的巨大变化可能是由于输注储存的血液的额外影响所致。
The effects of hemorrhagic shock and whole blood transfusions on red blood cell (RBC) Na+, K+, and ATP levels have been studied using two shock models. Group A animals were bled to a pressure of 40 mm Hg, following which no further blood was removed or returned. The blood pressure of these rats increased to approximately 70 mm Hg within 30 min and remained at that level for 2 hr. Group B animals were bled to a pressure of 40 mm Hg and maintained at that level for 2 hr. No significant changes in RBC Na+or K+levels were found in Group A animals subjected to shock. However, small but significant changes in RBC cations were observed in Group B animals subjected to hemorrhagic shock. In Group B, ATP levels decreased from 1.51 to 1.27 mmole/liter RBC. In another study (Group C), rats were subjected to shock as in Group B but were transfused with rat's whole blood which had been stored in cold ACD buffer for 6 days instead of their own shed blood. RBC Na+of Group C increased from 3.5 ± 0.1 to 8.4 ± 0.7, and K+decreased from 100.3 ± 2.3 to 85.0 ± 2.1. The RBC Na+of stored blood itself increased by 288 and 355% at 3 and 6 days cold storage, respectively. These results indicate that (1) severe hemorrhagic shock produces small changes in RBC Na+and K+levels; and (2) large changes in RBC cation levels which have been reported previously in man may be due to the additional effect of transfusion of stored blood.